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Kuan Rong Chan on Muck Rack

Kuan Rong Chan

As seen in: Medium, Nature, MDPI, Science Magazine, BioRxiv, Cell Press
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Articles

Dengue infection elicits skin tissue-resident and circulating CD8 + T cells associated with protection from hospitalization

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By Zhen He, Yudai Sato, Sophie R Shoemaker, Ka-Wai Cheung, Valerie Chew, Michaela Gregorova, Eugenia Ziying Ong, Kuan Rong Chan, Tun-Linn Thein, Yee-Sin Leo, Eng Eong Ooi, Laura Rivino, Noor Zayanah Hamis, Justin SG Ooi
| Science Magazine Verified
Abstract Dengue is spreading globally, and there is urgent need to define immune correlates of protection for this disease. Dengue infection first occurs in the skin following the bite of an infected mosquito; however, knowledge of host immune responses within this site remains sparse. We investigated the phenotypic, functional, and transcriptional profiles of skin and blood T cells in 73 patients with dengue and 10 healthy volunteers.
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Reduced dengue virus pre-membrane protein-HMGB1 interaction activates host cell transcription to attenuate infection - npj Vaccines

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By Tanamas Siriphanitchakorn, Summer Zhang, Dorothy Ng, Xin Yi Yap, Jia Yee, Qiao Zheng, Yi Tan, Eugenia Z. Ong, Kuan Rong Chan, Milly M. Choy, Eng Eong Ooi, Justin S. G. Ooi
| Nature Verified
Abstract To successfully complete an infection lifecycle, viruses have to avoid activating host antiviral and transcriptional responses to avoid disrupting cellular processes and cause premature host cell death. How the host transcriptional response to dengue virus (DENV) infection and its impact on pathogenesis, however, remain unclear.
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Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans

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By Shirin Kalimuddin, Yan Shan Leong, Jia Yee, Jenny Low, Kuan Rong Chan, Antonio Bertoletti
| Nature Verified
Abstract T cells have been identified as correlates of protection in viral infections. However, the level of vaccine-induced T cells needed and the extent to which they alone can control acute viral infection in humans remain uncertain. Here we conducted a double-blind, randomized controlled trial involving vaccination and challenge in 33 adult human volunteers, using the live–attenuated yellow fever (YF17D) and chimeric Japanese encephalitis–YF17D (JE/YF17D) vaccines.
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