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Articles by Kun Dou
Descriptor completion and cascade transfer for strength prediction in high strength steels
Abstract Accurate prediction of tensile strength (TS) and yield strength (YS) in high-strength steels (HSS) is hindered by incomplete microstructural reporting in literature-derived datasets, even though mechanical behaviour is governed by strong composition-process-structure-property coupling.
Structural basis of thymidine-rich DNA recognition by Drosophila P75 PWWP domain - Communications Biology
Abstract Drosophila P75 (dP75), a homolog of the human LEDGF/p75, is crucial for oogenesis by recruiting the histone kinase Jil-1 to euchromatin and impeding H3K9me2 spreading. Like LEDGF, dP75 binds transcriptionally active chromatin, but its precise mechanism remains unclear. Here we show that its PWWP domain prefers binding to thymidine-rich DNA over GC-rich sequences. Crystal structures both in apo and ssDNA-bound states, reveal a domain-swapped homodimer.
Metabolic Acidity/H2O2 Dual‐Cascade‐Activatable Molecular Imaging Platform Toward Metastatic Breast Tumor Malignancy
Conflict of Interests The authors declare no competing financial interest. Conflict of Interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset.
The Evolution of Dilatant Shear Bands in High Pressure Die Casting for Al-Si Alloy
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 1 October 2024 / Approved: 1 October 2024 / Online: 2 October 2024 (09:46:40 CEST) LU, J.; lordan, E.; Dou, K. The Evolution of Dilatant Shear Bands in High Pressure Die Casting for Al-Si Alloy. Preprints 2024, 2024100105. https://doi.org/10.20944/preprints202410.0105.v1 LU, J.; lordan, E.; Dou, K. The Evolution of Dilatant Shear Bands in High Pressure Die Casting for Al-Si Alloy. Preprints 2024, 2024100105.
Multifunctional Protein-Based Self-Assembled Nanoplatform: Overcoming Hypoxic Tumor Microenvironment for Enhanced Imaging-Guided Photodynamic Therapy
Multifunctional Protein-Based Self-Assembled Nanoplatform: Overcoming Hypoxic Tumor Microenvironment for Enhanced Imaging-Guided Photodynamic Therapy Photodynamic therapy (PDT) has emerged as a promising modality for cancer treatment, but its efficacy is often limited by tumor hypoxia. Here, we report the development of a novel protein-based, self-assembled nanoplatform, CAT-I-BODIPY NPs (CIB NPs), addressing this limitation.
Mechanism of Crack Propagation during Hot‐Rolling Process of a Medium‐Carbon 40Cr Alloy Steel
Abstract In this work, the mechanism of crack propagation during hot-rolling process of a typical medium-carbon 40Cr alloy steel is investigated by cracks characterization, thermodynamic calculation, and confocal laser scanning microscopy (CLSM). The depth of cracks is about 2.5 mm and its length along with rolling direction can even reach 2000–3000 mm.
Bioimaging of glutathione variation for early diagnosis of hepa-tocellular carcinoma using a liver-targeting ratiometric near-infrared fluorescent probe
Bioimaging of glutathione variation for early diagnosis of hepa-tocellular carcinoma using a liver-targeting ratiometric near-infrared fluorescent probe Fabiao Yu, Xiaoyue Han, Yanlong Xing, Xinyu Song, Kun Dou and Lingxin Chen Abstract Reliable biomarkers is crucial for early diagnosis of diseases and precise therapy. Biological thiols (represented with glutathione, GSH) play vital roles in the antioxidant defense system for maintaining intracellular redox homeostasis in organisms.
Probe Type II Band Alignment in One-Dimensional Van Der Waals Heterostructures Using First-Principles Calculations
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Hijacking Oogenesis Enables Massive Propagation of LINE and Retroviral Transposons
Although animals have evolved multiple mechanisms to suppress transposons, “leaky” mobilizations that cause mutations and diseases still occur. This suggests that transposons employ specific tactics to accomplish robust propagation. By directly tracking mobilization, we show that, during a short and specific time window of oogenesis, retrotransposons achieve massive amplification via a cell-type-specific targeting strategy. Retrotransposons rarely mobilize in undifferentiated germline stem cells.
Bright sensitive ratiometric fluorescent probe enabling endogenous FA imaging and mechanistic exploration of indirect oxidative damage of FA in various living systems - Chemical Science (RSC Publishing)
As a notorious toxin, formaldehyde (FA) poses immense threat to human health. Aberrantly elevated FA leads to serious pathologies including organism damage, neurodegeneration, and cancer. Unfortunately, current techniques limit FA imaging to the general comparative studies, instead of the mechanistic exploration on its biological role, which is presumably due to the lack of robust molecular tool for reporting FA in living systems.
A Two-Photon ratiometric Fluorescent Probe for the Synergistic Detection of Mitochondrial SO2/HClO Crosstalk in Cells and in Vivo
Known as a new member of reactive sulphur species (RSS), endogenous sulfur dioxide (SO2) plays potential reductive roles in antioxidant, anti-aging, anti-inflammatory and cytoprotection. However, SO2 is also a metabolite of antioxidant. Hypochlorous acid (HClO) has powerful bioeffects on the innate immune system, its uncontrolled production leads to adverse damages in cells.
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