Kun Xia
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Articles by Kun Xia
NEK2 Promotes OSCC Invasion and Metastasis by Activating TNF-α Signaling Through Impairment of Desmosomal Adhesion
Disclosure Declaration of artificial intelligence (AI) assistance: During the preparation of this manuscript, we used artificial intelligence (AI)-assisted tools solely for language polishing, grammar checking, and writing assistance. No AI tools were used for generating core scientific ideas, interpreting data, drawing conclusions, producing figures or tables, or conducting any form of data analysis.
Explainable random forest–SHAP framework for Montreal phenotype–stratified prediction of one-year complications in Crohn’s disease
Abstract Background: Early identification of phenotype-stratified, short-term complication risk remains a critical unmet need in Crohn’s disease (CD). Existing models focus on single outcomes and lack interpretability, limiting clinical use. We developed a clinically interpretable machine-learning framework to enable Montreal phenotype–stratified prediction of three one-year complication categories: bowel resection (Task 1), perianal complications (Task 2), and abdominal complications (Task 3).
Major urinary protein 1 modulates neuronal excitability in the medial prefrontal cortex in a male mouse model of affective empathy
Abstract Affective empathy describes the capacity to share others’ emotions, yet the molecular mechanisms governing individual differences in empathic sensitivity remain poorly understood. Using a male mouse model of social transmission of depression (STD), we demonstrated that STD‑sensitive observer mice exhibit heightened neuronal excitability and upregulated major urinary protein 1 (MUP1) expression in the medial prefrontal cortex (mPFC) compared with STD‑insensitive observer mice.
Genomic landscape of rare variants in a Chinese autism cohort and discovery of novel risk genes
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Abstract Autism spectrum disorder (ASD) is a genetically complex neurodevelopmental condition with a high heritability. However, genomic studies of ASD have been underrepresented in East Asian populations, and the molecular yield in ASD cohorts remains modest. Here, we present a whole-genome sequencing analysis of 3109 samples across 1033 Chinese ASD families.
By Senwei Tan, Yongqing Lyu, Xiaoyue Sun, Ruolan Guo, Xiaolei Zhang, Zhuo Song, Kewen Chen, Yi Zheng, Canhui Jiang, Cai Qin, Ting Bai, Juan Li, Zhigao Long, Qian Pan, Jieqiong Tan, Ningxia Zhao, Yu Zhang, Yidong Shen, Jianjun Ou, Yonghua Cui, Chanjuan Hao, Xiangbin Jia, Lu Xia, Jinchen Li, Zhengmao Hu, Wei Li, Hui Guo, Kun Xia, Chenzhang Li, Guizhi Tang
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Nature
Verified
Sigmoid colonic tuberculosis presenting as a colovesical fistula mimicking colorectal malignancy: a case report
Abstract Background: Intestinal tuberculosis (ITB) most commonly involves the ileocecal region. Isolated sigmoid colonic tuberculosis complicated by a colovesical fistula is extremely rare and may closely mimic colorectal malignancy or Crohn's disease (CD). Case presentation: A 73-year-old man presented with subacute diarrhea, fever, and lower urinary tract symptoms. Laboratory tests showed markedly elevated inflammatory markers and anemia.
The genetic spectrum of LRRK2 variants in Parkinson’s disease: findings from a large Chinese cohort
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Abstract The pathogenicity of variants of uncertain significance in the LRRK2 gene remains underexplored. Investigating the LRRK2 variant spectrum in a large Chinese population cohort can provide deeper insights into its pathogenic mechanisms. This study examined the LRRK2 gene variants in 20,519 Chinese individuals, including 7,562 Parkinson’s disease (PD) patients, 3,077 Essential tremor (ET) patients, and 9880 healthy controls.
By Juan Wan, Hongxu Pan, Dong Eui Chang, Yuwen Zhao, qian Xu, Qiying Sun, Xuewei Zhang, Runcheng He, Chunyu Wang, Hainan Zhang, Lifang Lei, Yuzheng Wang, Mingqiang Li, Heng Wu, Jinghong Ma, Yiwen Wu, Yan Xu, Nian Xiong, Tao Wang, Xuejing Wang, Ling Chen, Yanming Xu, Hongmei Cao, Kezhong Zhang, Weiguo Liu, Yuhu Zhang, Chengjie Mao, Qing Wang, Zheng Xue, Zhentao Zhang, Oumei Cheng, Wei Huang, Guohua Zhao, Guiyun Cui, Tao Chen, Puqing Wang, Wei Di, Hong liu, Houfeng Zheng, Chao Chen, Hui Guo, Kun Xia, Zhuohua Zhang, Kai Yuan, Jinchen Li, Junling Wang, Jifeng Guo, Lu Shen, Hong Jiang, Chunfeng Liu, Jun Liu, Piu Chan, Zhenhua Liu, Beisha Tang, Parkinson’s Disease, Lingyan Yao
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Nature
Verified
Simulation Study on Axis Offset Prediction of Convolutional Neural Network Based on Structured Light
1. Introduction In the realm of mechanics, shaft misalignment leads to unstable equipment operation, which has an impact on service life and accuracy. Traditional detection approaches employ mechanical devices such as laser rangefinders or calipers. However, typical contact-based measurement methods—such as dial indicator techniques—are unsuitable for high-speed spindle inspection, while single-point methods often suffer from limited accuracy and restricted applicability [1].
Case Report: successful treatment of severe bronchiectasis by inhalation of mesenchymal stem cell-derived exosomes
1 Introduction Bronchiectasis, a chronic disorder characterized by abnormal and permanent dilatation of the bronchi (1). Despite standard prolonged antibiotic therapy, approximately 50% of patients experience ≥2 annual exacerbations, with one-third requiring hospitalization (2). More severe and more frequent exacerbations accelerate lung function decline, impair quality of life, and mortality (3, 4), which poses a severe threat to human health.
Tetrahydroxydiboron-Mediated Synthesis of α-Sulfonyl Ketoximes from Nitroalkenes and Sodium Sulfinates
The Journal of Organic Chemistry Cite this: J. Org. Chem. 2025, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
TEMPO-Catalyzed Electrochemical Hydrobenzylation of Imines with Methylarenes via Radical Cascade Reaction
Cite Jump to ExpandCollapse ArticleSeptember 30, 2025 TEMPO-Catalyzed Electrochemical Hydrobenzylation of Imines with Methylarenes via Radical Cascade Reaction Click to copy article linkArticle link copied! Kaifa Zhang Kaifa Zhang State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources, College of Chemistry, Xinjiang University, Urumqi 830017, China Kun Xia Kun Xia State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources, College of...
Visible Light-Induced Radical-Cascade Difluoroalkylation/Cyclization of Unsaturated Aldehyde Hydrazones for the Synthesis of Difluoroalkylated Dihydropyrazoles and Tetrahydropyridazines
The Journal of Organic Chemistry Cite this: J. Org. Chem. 2025, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
Aberrant Short Tandem Repeats: Pathogenicity, Mechanisms, Detection, and Roles in Neuropsychiatric Disorders
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
[2412.03212] Semi-Supervised Transfer Boosting (SS-TrBoosting)
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Factors influencing compliance with pulmonary rehabilitation in patien
Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 20 Authors Xia X, Xia K, Yao X , Song J, Liu Y, Liu X, Zhang H, Li G Received 13 November 2024 Accepted for publication 22 March 2025 Published 31 March 2025 Volume 2025:20 Pages 895—904 DOI https://doi.org/10.2147/COPD.S506248 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Min Zhang Xiao Xia,1,2 Kun Xia,1 Xiaoyan...
Monoallelic loss-of-function variants in GSK3B lead to autism and developmental delay - Molecular Psychiatry
Abstract De novo variants adjacent to the canonical splicing sites or in the well-defined splicing-related regions are more likely to impair splicing but remain under-investigated in autism spectrum disorder (ASD). By analyzing large, recent ASD genome sequencing cohorts, we find a significant burden of de novo potential splicing-disrupting variants (PSDVs) in 5048 probands compared to 4090 unaffected siblings.
A metabolomic profile of biological aging in 250,341 individuals from the UK Biobank - Nature Communications
Abstract The metabolomic profile of aging is complex. Here, we analyse 325 nuclear magnetic resonance (NMR) biomarkers from 250,341 UK Biobank participants, identifying 54 representative aging-related biomarkers associated with all-cause mortality.
Effect of Y2O3 Content on Microstructure and Wear Resistance of Laser Cladding Layer of Stellite-6 Alloy
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Autism patient-derived SHANK2BY29X mutation affects the development of ALDH1A1 negative dopamine neuron - Molecular Psychiatry
Abstract Autism spectrum disorder (ASD) encompasses a range of neurodevelopmental conditions. Different mutations on a single ASD gene contribute to heterogeneity of disease phenotypes, possibly due to functional diversity of generated isoforms. SHANK2, a causative gene in ASD, demonstrates this phenomenon, but there is a scarcity of tools for studying endogenous SHANK2 proteins in an isoform-specific manner.
Visible light-induced oxidative esterification of mandelic acid with alcohols: a new synthesis of α-ketoesters
Visible light-induced oxidative esterification of mandelic acid with alcohols: a new synthesis of α-ketoesters A visible light-induced oxidative esterification reaction of mandelic acids with alcohols has been developed for the synthesis of α-ketoesters. The reaction is characterised by transition metal-free, good yields, broad functional group tolerance and ease of operation.
Optoelectronic Torque Measurement System Based on SAPSO-RBF Algorithm
1. Introduction Torque is one of the fundamental parameters in rotational mechanical systems, playing a pivotal role in various engineering activities which involve the use of rotating machinery [1,2,3]. Its significance spans across industries such as mechanical manufacturing [4], automotive manufacturing [5], aerospace engineering [6], maritime sectors [7], and other related fields.
transition metal-free C(sp3)-H selenation of β-ketosulfones
transition metal-free C(sp3)-H selenation of β-ketosulfones The installation of selenium groups has become an essential step across a number of industries such as agrochemicals, drug discovery, and materials. However, direct C(sp3)-H selenation, which is most atom economical, remains a formidable challenge, and only a few examples have been reported to date.
Delta hedging and volatility-price elasticity: A two-step approach
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