Kun Yin
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Clinical factors associated with 30-day heart failure readmission in patients with acute decompensated heart failure with preserved ejection fraction
Abstract Background: In acute decompensated heart failure with preserved ejection fraction (ADHFpEF), residual congestion before discharge is closely related to early heart failure (HF) readmission. This study evaluated the clinical factors associated with 30-day HF readmission in patients with ADHFpEF. Methods: This single-center retrospective study included 312 adults discharged after hospitalization for ADHFpEF between January 2020 and December 2024.
Metabolic RNA Labeling-Enabled Time-Resolved Single-Cell RNA Sequencing
Abstract Click to copy section linkSection link copied! Conspectus Gene expression of cells is a highly heterogeneous and dynamic program that changes over time in various biological processes such as embryogenesis, disease progression, and response to stimuli. Understanding the molecular mechanisms of heterogeneous and dynamic gene expression is crucial for advancing our knowledge of health and disease.
Simultaneous Measurement of RNA Synthesis and Degradation Rates in Single Cells Unveils the Regulatory Mechanisms of Temporal RNA Dynamics
Conflict of Interests C.Y., S.W., and S.L. are inventors of a patent application related to this work. C.Y. is a co-founder of Dynamic Biosystems. The other authors declare no competing interests. Supporting Information Filename Description anie202510939-sup-0001-SuppMat.docx3.9 MB Supporting Information References 1, , , , Dev. Cell 2004, 6, 117–131. 2, , , Nature 2002, 418, 293–300. 3, , , Nat. Rev. Genet. 2011, 12, 833–845. 4, , , , , , , , , , , , Cell 2014, 159, 1698–1710.
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