Kun Yin
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Metabolic RNA Labeling-Enabled Time-Resolved Single-Cell RNA Sequencing
Abstract Click to copy section linkSection link copied! Conspectus Gene expression of cells is a highly heterogeneous and dynamic program that changes over time in various biological processes such as embryogenesis, disease progression, and response to stimuli. Understanding the molecular mechanisms of heterogeneous and dynamic gene expression is crucial for advancing our knowledge of health and disease.
Simultaneous Measurement of RNA Synthesis and Degradation Rates in Single Cells Unveils the Regulatory Mechanisms of Temporal RNA Dynamics
Conflict of Interests C.Y., S.W., and S.L. are inventors of a patent application related to this work. C.Y. is a co-founder of Dynamic Biosystems. The other authors declare no competing interests. Supporting Information Filename Description anie202510939-sup-0001-SuppMat.docx3.9 MB Supporting Information References 1, , , , Dev. Cell 2004, 6, 117–131. 2, , , Nature 2002, 418, 293–300. 3, , , Nat. Rev. Genet. 2011, 12, 833–845. 4, , , , , , , , , , , , Cell 2014, 159, 1698–1710.
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