Kwanha Yu

Abstract ZFTA–RELA is the most recurrent genetic alteration seen in paediatric supratentorial ependymoma (EPN) and is sufficient to initiate tumours in mice1. Despite its oncogenic potential, ZFTA–RELA (ZR) is observed nearly exclusively in childhood EPN, with tumours located distinctly in the supratentorial brain of the central nervous system1.

Keywords Child, Female, Pregnancy, Humans, Astrocytes, Gene Expression Profiling, Brain, Transcriptome, Cerebellum, Brain Neoplasms, Cerebellar Neoplasms, astrocyte, transcriptome, cerebellum, postnatal development, pediatric brain tumors Abstract Astrocytes are the most abundant glial cell type in the central nervous system, and they play a crucial role in normal brain function.

Keywords Glioblastoma, Animals, Brain Neoplasms, Mice, Humans, Nerve Net, Glutamic Acid, Neurons, Cerebral Cortex, Calcium Signaling, Disease Models, Animal, Male, Calcium, Female, Cancer in the nervous system, CNS cancer, Astrocyte, Cancer microenvironment, CNS cancer Abstract The emergence of glioblastoma in cortical tissue initiates early and persistent neural hyperexcitability with signs ranging from mild cognitive impairment to convulsive seizures.