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Tuyu Zheng

As seen in: Nature, Cancer Discovery
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Articles

Dominant clones leverage developmental epigenomic states to drive ependymoma

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By Alisha Kardian, Hua Sun, Siri Ippagunta, Nicholas Laboe, Srinidhi Varadharajan, Kwanha Yu, Hsiao-Chi Chen, Tuyu Zheng, Jon P. Connelly, Yong-Dong Wang, Jiangshan Zhan, Hengxi Liu, Kimberley Lowe, Taylor Bugbee, Rakesh Pathak, Amanda Bland, Sanya Mehta, Amir Arabzade, Blake Holcomb, Tristen Wright, David S. Gee, Yi Xiao, Samuel K. McBrayer, Thomas E. Merchant, Jun Qi, Adam D. Durbin Verified, Lindsay A. Schwarz, Li Wang, Andrew M Donson, Nicholas Foreman, Sameer Agnihotri, Alfonso Lavado, Suzanne Baker, David Ellison, Hyun Lee, Shondra M. Pruett-Miller, Kelsey C. Bertrand, Benjamin Deneen, Stephen Mack, Erik Emanus, Riley M. Deneen, Sophie Cochiolo, Kaitlin M. Budd, Gabriele Kembuan, Emma Caesar, Amelia Hancock, Joel Murdoch
| Nature Verified
Abstract ZFTA–RELA is the most recurrent genetic alteration seen in paediatric supratentorial ependymoma (EPN) and is sufficient to initiate tumours in mice1. Despite its oncogenic potential, ZFTA–RELA (ZR) is observed nearly exclusively in childhood EPN, with tumours located distinctly in the supratentorial brain of the central nervous system1.
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Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models - Nature Genetics

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By Melanie Schoof, Tuyu Zheng, Martin Sill, Roland Imle, Kati J. Ernst, Michael Spohn, Carolin Göbel, Levke-Sophie Peter, Franck Bourdeaut, Fredrik J. Swartling, Jessica Taylor, Richard J. Gilbertson, Kornelius Kerl, Gerrit Wolters-Eisfeld, Haotian Zhao, Louis Chesler, Simon J. Haas, Paul A. Northcott, Lena M. Kutscher, Ana Guerreiro Stucklin, Olivier Ayrault, Julia E. Neumann, Ana Banito, Stefan M. Pfister, Ulrich Schüller
| Nature Verified
Abstract Copy number alterations (CNAs) are hallmarks of cancer, yet investigation of their oncogenic role has been hindered by technical limitations and missing model systems. Here we generated a genome-wide DNA methylation and CNA atlas of 106 genetic mouse models across 31 pediatric tumor types, including 18 new models for pediatric glioma. We demonstrated their epigenetic resemblance to human disease counterparts and identified entity-specific patterns of immune infiltration.
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Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion-positive supratentorial ependymomas

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By Tuyu Zheng, David R. Ghasemi, Konstantin Okonechnikov, Andrey Korshunov
| hal.science
Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion-positive supratentorial ependymomas Mots clés Ependymoma Supratentorial PLAGL1 EWSR1 FOXO1 EP300 Gene fusion Fichier principal Brandner_PLAGL1_EPN.pdf (980.68 Ko) Télécharger le fichier Origine Fichiers produits par l'(les) auteur(s)
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