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Articles by Lan Sun
Urea transporter B–mediated urea uptake–induced protein carbamylation in platelets underlies bleeding in chronic kidney disease
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Patients with advanced chronic kidney disease (CKD) can have platelet dysfunction and consequent bleeding complications with no clear therapeutic options. Qiu et al. found that urea transporter B (UT-B), encoded by the SLC14A1 gene, may regulate bleeding in advanced CKD.
Water-state control unlocks durable and elastic silk fibroin hydrogels
Abstract Protein hydrogels are highly valued for their biocompatibility and biodegradability, yet their practical use has been limited by poor mechanical strength and dehydration. Polymer‒water interactions govern hydrogel mechanics, whereas dehydration causes failure, rendering water retention and hydration-mediated mechanics critical research focuses.
The safety and efficacy of belumosudil and ruxolitinib combination in ruxolitinib refractory cGVHD
Chronic graft-versus-host disease (cGVHD) remains a major barrier to long-term survival post allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients [1]. It was the leading cause of late non-relapse mortality (NRM), contributing to organ disfunction, infections and poor quality of life. More than 50% patients developed steroids refractory (SR) cGVHD when accepting corticosteroids and calcineurin inhibitor treatments [2].
Restorative Challenges: Reconstruction of Large Axillary Defects Following Surgery for Extramammary Paget’s Disease
Introduction EMPD is a rare malignant cutaneous neoplasm arising in apocrine gland–bearing skin.
Combined F‐wave and AF Duration Predict Post‐Ablation Recurrence in Persistent AF: Dual‐Center Study
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description pace70064-sup-0001-SuppMat.docx13.4 KB Table S4: Summary of Ablation Strategies and Procedural Outcomes. References 1, , and , “Impact of Atrial Fibrillation on the Risk of Death: The Framingham Heart Study,” Circulation 98, no. 10 (1998): 946–952. 2, , and , “Epidemiology and Modifiable Risk Factors for Atrial Fibrillation,” Nature Reviews Cardiology 20, no. 6 (2023): 404–417.
The significance of fat-free body mass index for assessing disease sta
Introduction Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition characterized by progressive and worsening airflow limitation. The primary manifestations of this disease include chronic respiratory symptoms such as cough, sputum production, and dyspnea.
Transcutaneous auricular vagus nerve stimulation ameliorates adolescent depressive‐ and anxiety‐like behaviors via hippocampus glycolysis and inflammation response
1 INTRODUCTION Adolescence constitutes a pivotal period for the maturation of neurocognitive processes, during which stress impacts brain development and results in an augmented vulnerability to mental disorders in later life.1, 2 Exposure to early life adversity (ELA) is a well-established predictor of stress-related psychopathologies such as depression.3-7 The link between ELA and aberrant cognitive behaviors in maturity is well supported by preclinical models of peri-adolescent...
Construction of nanoparticle-on-mirror nanocavities and their applications in plasmon-enhanced spectroscopy
Construction of nanoparticle-on-mirror nanocavities and their applications in plasmon-enhanced spectroscopy Plasmonic nanocavities exhibit exceptional capabilities in visualizing the internal structure of a single molecule at sub-nanometer resolutions. Among these, an easily manufacturable nanoparticle-on-mirror (NPoM) nanocavity is a successful and powerful platform for demonstrating various optical phenomena.
The Advances, Challenges, and Perspectives on Electrocatalytic Reduction of Nitrogenous Substances to Ammonia: A Review
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
ACNPs loaded with metformin against hepatocellular CSCs
Introduction Hepatocellular cancer is the third leading cause of cancer death worldwide and its incidence is increasing.
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