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Lanying Zeng on Muck Rack

Lanying Zeng

As seen in: Nature, Science Magazine, BioRxiv, Cell Press, The Journal of Biological Chemistry
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Articles

Lethal permeabilization of host bacteria to small-molecule compounds during phage penetration

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By Zihao Yu, Chaohua Wu, Harrison Lee, Ian Mattingly, Ryland Young, Lanying Zeng, Lily Torrans
| Nature Verified
Abstract Tailed phages (Caudoviricetes) inject their double-stranded linear genomic DNA across the bacterial envelope to initiate infection. During this DNA entry process, ionic fluxes and membrane depolarization may occur, potentially leading to increased vulnerability to antibiotic molecules. Here, we report that phage DNA translocation combined with certain small molecules triggers rapid and phage-specific cell permeabilization leading to bacterial growth arrest.
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Spatial propagation of temperate phages within and among biofilms

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By James B. Winans, Sofía García, Lanying Zeng, Carey D. Nadell
| BioRxiv
Abstract Bacteria form groups comprised of cells and a secreted polymeric matrix that controls their spatial organization. These groups - termed biofilms - can act as refuges from environmental disturbances and from biotic threats, including phages. Despite the ubiquity of temperate phages and bacterial biofilms, live propagation of temperate phages within biofilms has never been characterized on cellular spatial scales.
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Structural mechanisms of Tad pilus assembly and its interaction with an RNA virus

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By Bingjie Hao, Sicong He, Yuhang Wang, Matthew Theodore, Zhongliang Xing, Zihao Yu, Lanying Zeng, Junjie Zhang, Utkarsh Narsaria
| Science Magazine Verified
Research Article STRUCTURAL BIOLOGY Yuhang Wang https://orcid.org/0000-0002-8048-138X, Matthew Theodore https://orcid.org/0000-0003-0625-7141, [...] , Zhongliang Xing https://orcid.org/0000-0003-2142-6230, Utkarsh Narsaria, [...] , Zihao Yu https://orcid.org/0000-0001-5431-2075, Lanying Zeng https://orcid.org/0000-0002-8074-5824, and Junjie Zhang https://orcid.org/0000-0002-7912-0819 junjiez@tamu.edu+4 authors +2 authors fewerAuthors Info & Affiliations Abstract Caulobacter crescentus Tad...
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