Larance Ronsard

eLife Assessment This valuable manuscript describes the immunogenicity of a bead-on-a-string immunogen that allows the inclusion of multiple HA subtypes. The evidence to support the claims is convincing, and more importantly, this approach could be adapted to other vaccine platforms.

Abstract Recruitment and expansion of rare precursor B cells in germinal centers (GCs) is a central goal of vaccination to generate broadly neutralizing antibodies (bnAbs) against challenging pathogens such as HIV. Multivalent immunogen display is a well-established method to enhance vaccine-induced B cell responses, typically accomplished by using natural or engineered protein scaffolds.

Keywords influenza virus broadly neutralizing antibody bnAb hemagglutinin germline-targeting HA stem nanoparticle B cell IGHV1-69 IGHD3-9 Research topic(s) CP: Immunology Introduction Influenza A and B viruses cause seasonal epidemics and hundreds of thousands of hospitalizations and deaths every year.1 Influenza A viruses (IAVs) have also been responsible for four major global pandemics in the last 110 years.