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ArticleVolume 85, Issue 24p4492-4509.e11Open access 1University of Toulouse UT, CNRS, CBI, MCD, Toulouse, France 2University of Toulouse UT, CNRS, CBI, BigA, NGS Data Analysis Facility, Toulouse, France 3University of Toulouse UT, CNRS, CBI, LITC Core Facility, Toulouse, France 4University of Toulouse UT, CNRS, Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse, France 5Equipe Labellisée Ligue Contre le Cancer 2018, Toulouse, France 6Institut National de la Santé et de la...
Abstract Repair of DNA Double-Strand Breaks (DSBs) produced in transcriptionally active chromatin occurs through a poorly characterized pathway called Transcription-Coupled DSB repair (TC-DSBR). Here, using a screening approach scoring multiple outputs in human cells, we identified proteins from the PERIOD complex, a key module ensuring circadian oscillations, as novel TC-DSBR players.
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