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Laurent Bartholin

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Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features | Nature Communications

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By Dustin Flanagan, Raheleh Amirkhah, Hayley Davis, Rachel A. Ridgway, Colin Nixon, Ann Hedley, Douglas Strathdee, Laurent Bartholin, Emma Kerr, Alberto Bardelli, Andrew Campbell, Simon T. Barry, Gareth J. Inman, Jacco van Rheenen, Philip Dunne
| Nature Verified
Author notes These authors contributed equally: Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent, Philip D. Dunne, Owen J. Sansom. Authors and Affiliations Cancer Research UK Beatson Institute, Glasgow, UK Dustin J. Flanagan, David F. Vincent, Nuray Gunduz, Pauline Gentaz, Patrizia Cammareri, Rachel A. Ridgway, Joshua D. G. Leach, Rene Jackstadt, Kathryn Gilroy, Colin Nixon, William Clark, Ann Hedley, Elke K. Markert, Douglas Strathdee, Andrew D. Campbell, Gareth J. Inman, Philip D. Dunne & Owen J.
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Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features - Nature Communications

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By Dustin Flanagan, Raheleh Amirkhah, Hayley Davis, Rachel A. Ridgway, Colin Nixon, Ann Hedley, Douglas Strathdee, Laurent Bartholin, Emma Kerr, Alberto Bardelli, Andrew Campbell, Simon T. Barry, Gareth J. Inman, Jacco van Rheenen, Philip Dunne
| Nature Verified
Abstract The pro-tumourigenic role of epithelial TGFβ signalling in colorectal cancer (CRC) is controversial. Here, we identify a cohort of born to be bad early-stage (T1) colorectal tumours, with aggressive features and a propensity to disseminate early, that are characterised by high epithelial cell-intrinsic TGFβ signalling.
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