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Ledia Brunga

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Articles by Ledia Brunga

Prior therapy defines mutation profiles in childhood cancer at relapse

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By Mehdi Layeghifard, Marcos Díaz-Gay, Erik Bergström, Mathepan Mahendralingam, Nicholas Light, Sasha Blay, Joshua Nash, Nathaniel Anderson, Jessica Au, Scott Davidson, S. Islam, Azhar Khandekar, Burcak Otlu, Ledia Brunga, Rawan Hammad, Nirav Thacker, Noemi Fuentes-Bolanos, Marie Wong-Erasmus, Max Levine, Katherine Miller Verified, Neerav Shukla, Michael D. Kinnaman, Dominik Glodzik, Carol Portwine, Mariam Mikhail, Conrad V. Fernandez, Laura Wheaton, Gunes Gundem, Andrew Kung, Uri Tabori, Chelsea Mayoh, Elli Papaemmanuil, Mark Cowley, David Malkin, Anita Villani, Ludmil B. Alexandrov, Adam Shlien, Pedro L. Ballester, Timmy Wen, Syed Kashif Daud, Lisa-Monique Edward, Shimaa Nassif, Tara Feltham, Sabrina Millson, Alexandra P. Zorzi
| Nature Verified
Abstract Children with cancer develop many short- and long-term side-effects of treatment1, but the amount of DNA damage associated with chemotherapy exposure is unclear2. Here we used mutational signatures to measure this damage using whole-genome-sequenced tumours from a multi-institutional cohort for which therapy dose and total exposure were uniformly collected3,4,5.
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Perspectives and Experiences of Parents and Adolescents Who Participate in a Pediatric Precision Oncology Program: "When You Feel Helpless, This Kind of Thing Is Very Helpful" | JCO Precision Oncology

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By Larissa Waldman, Kelly Hancock, Brittney Johnstone, Ledia Brunga
| ascopubs.org
Abstract The SickKids Cancer Sequencing (KiCS) Program, launched in 2016, evaluates the clinical utility of paired tumor/germline Next-Generation Sequencing (NGS) in pediatric oncology patients with hard-to-cure and rare cancers. In anticipation of further widespread adoption of NGS, we aimed to characterize the experiences and perspectives of adolescents and parents of patients who have already undergone NGS evaluation, focusing on the psychosocial impact and personal utility.
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