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Timmy Wen

As seen in: Nature
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Articles

Prior therapy defines mutation profiles in childhood cancer at relapse

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By Mehdi Layeghifard, Marcos Díaz-Gay, Erik Bergström, Mathepan Mahendralingam, Nicholas Light, Sasha Blay, Joshua Nash, Nathaniel Anderson, Jessica Au, Scott Davidson, S. Islam, Azhar Khandekar, Burcak Otlu, Ledia Brunga, Rawan Hammad, Nirav Thacker, Noemi Fuentes-Bolanos, Marie Wong-Erasmus, Max Levine, Katherine Miller Verified, Neerav Shukla, Michael D. Kinnaman, Dominik Glodzik, Carol Portwine, Mariam Mikhail, Conrad V. Fernandez, Laura Wheaton, Gunes Gundem, Andrew Kung, Uri Tabori, Chelsea Mayoh, Elli Papaemmanuil, Mark Cowley, David Malkin, Anita Villani, Ludmil B. Alexandrov, Adam Shlien, Pedro L. Ballester, Timmy Wen, Syed Kashif Daud, Lisa-Monique Edward, Shimaa Nassif, Tara Feltham, Sabrina Millson, Alexandra P. Zorzi
| Nature Verified
Abstract Children with cancer develop many short- and long-term side-effects of treatment1, but the amount of DNA damage associated with chemotherapy exposure is unclear2. Here we used mutational signatures to measure this damage using whole-genome-sequenced tumours from a multi-institutional cohort for which therapy dose and total exposure were uniformly collected3,4,5.
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