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Joshua Nash on Muck Rack

Joshua Nash

As seen in: Nature, Environmental Communication, The Conversation, SBS, The Feed (SBS), Good Therapy, Mondaq, The Justice Gap
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Articles

Prior therapy defines mutation profiles in childhood cancer at relapse

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By Mehdi Layeghifard, Marcos Díaz-Gay, Erik Bergström, Mathepan Mahendralingam, Nicholas Light, Sasha Blay, Joshua Nash, Nathaniel Anderson, Jessica Au, Scott Davidson, S. Islam, Azhar Khandekar, Burcak Otlu, Ledia Brunga, Rawan Hammad, Nirav Thacker, Noemi Fuentes-Bolanos, Marie Wong-Erasmus, Max Levine, Katherine Miller Verified, Neerav Shukla, Michael D. Kinnaman, Dominik Glodzik, Carol Portwine, Mariam Mikhail, Conrad V. Fernandez, Laura Wheaton, Gunes Gundem, Andrew Kung, Uri Tabori, Chelsea Mayoh, Elli Papaemmanuil, Mark Cowley, David Malkin, Anita Villani, Ludmil B. Alexandrov, Adam Shlien, Pedro L. Ballester, Timmy Wen, Syed Kashif Daud, Lisa-Monique Edward, Shimaa Nassif, Tara Feltham, Sabrina Millson, Alexandra P. Zorzi
| Nature Verified
Abstract Children with cancer develop many short- and long-term side-effects of treatment1, but the amount of DNA damage associated with chemotherapy exposure is unclear2. Here we used mutational signatures to measure this damage using whole-genome-sequenced tumours from a multi-institutional cohort for which therapy dose and total exposure were uniformly collected3,4,5.
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An international framework for clinical translation of molecular classifiers in osteosarcoma

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By Amanda E. Marinoff, Michaela Nathrath, David Shulman, Sarah Whittle, Jovana Pavisic, Dimitrios Spentzos, Catherine M. Albert, Joshua Nash, Adam Shlien, Isidro Cortes-Ciriano, Antonin Marchais, Eunice López-Fuentes, Christina Curtis, E. Alejandro Sweet-Cordero, Richard Gorlick, Natalie J. DelRocco, Rashmi Chugh, William D Tap, Adrienne M. Flanagan, Nathalie Gaspar, Brian D. Crompton, Damon R. Reed, Katherine A. Janeway, Patrick Grohar, J. Andrew Livingston, Ryan Roberts
| Nature Verified
Abstract Despite well-recognized biological heterogeneity, osteosarcoma has been treated as a single disease for over four decades with minimal improvement in survival. Clinical features are inadequate for risk stratification, and no molecular classifiers guide therapy. An international working group evaluated candidate prognostic biomarkers for clinical translation.
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Inter-chromosomal contacts demarcate genome topology along a spatial gradient - Nature Communications

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By Jordan Chalmers, Son Nguyen, Joshua Nash, Sergio Espeso-Gil, A. Rasim Barutcu, Michael Wilson, Thomas Liehr, Adam Shlien, Samin Aref, Milad Mokhtaridoost, Marzieh Soleimanpoor, Brandon J. McMurray, Daniella F. Lato
| Nature Verified
Abstract Non-homologous chromosomal contacts (NHCCs) between different chromosomes participate considerably in gene and genome regulation. Due to analytical challenges, NHCCs are currently considered as singular, stochastic events, and their extent and fundamental principles across cell types remain controversial. We develop a supervised and unsupervised learning algorithm, termed Signature, to call NHCCs in Hi-C datasets to advance our understanding of genome topology.
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