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Lehua Yin on Muck Rack

Lehua Yin

As seen in: Nature
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Articles

Prasugrel inhibits TLR7-driven autoimmunity in systemic lupus erythematosus by acetylating cGAS

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By Zeng-Lin Guo, Shuai Jiang, Ming Zhao, Yuhui Li, Jinjing Qian, Yakai Fu, Chunmei Wu, Ying Yuan, Wen Xue, Xucheng Lv, Xingxing Yang, Peng-Peng Zhu, Yu Yu, Xin Xu, Kai Wang, Qiu-Ying Han, Zhuoxin Li, Zhi-Hui Su, Jiaqi Wu, Hong Cai, Tian Xia, Yuan Chen, Xue-Min Zhang, Wei-Hua Li, Tao Zhou, Zhanguo Li, Qiong Fu, Xinhua He, Tao Li, Li-Ming Sun, Shao-Zhen Jiang, Sen-Chao Yuan, Lehua Yin, Xi-Ping Yu, Ai-Ling Li
| Nature Verified
Abstract Systemic lupus erythematosus (SLE) has a complex, multifactorial etiology, which contributes to a lack of definitive cure and limited treatment efficacy. Here, we report that cyclic GMP-AMP synthase (cGAS) is significantly activated in SLE patients. We further demonstrate that cGAS deletion protects mice from lupus-like symptoms induced by the TLR7 agonist imiquimod (IMQ). In a screen of 3,159 FDA-approved drugs, we identify the antiplatelet agent prasugrel as a potent cGAS inhibitor.
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