Lennard Wiesner on Muck Rack

Lennard Wiesner

As seen in: Nature, Cell Press
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Articles

Deep learning of functional perturbations from condensate morphology

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By Anita Donlic, Troy J. Comi, Sofia A Quinodoz, Nima Jaberi-Lashkari, Krist Antunes Fernandes, Lifei Jiang, Lennard Wiesner, Clifford P. Brangwynne
| Cell Press Verified
Keywords biomolecular condensate high-content imaging deep learning morphological profiling RNA biochemistry nucleolus nuclear speckle RSV TOP1 Introduction Spatial compartmentalization of biomolecular interactions is key to achieving complex cellular functions.
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Mapping and engineering RNA-driven architecture of the multiphase nucleolus - Nature

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By Sofia A Quinodoz, Lifei Jiang, Aya A Abu-Alfa, Troy J. Comi, Qiwei Yu, Lennard Wiesner, Prashant Bhat, Christiane Zorbas, Ludivine Wacheul, Andrej Košmrlj, Sebastian Klinge, Jordy F. Botello
| Nature Verified
Abstract Biomolecular condensates are key features of intracellular compartmentalization1,2. As the most prominent nuclear condensate in eukaryotes, the nucleolus is a multiphase liquid-like structure in which ribosomal RNAs (rRNAs) are transcribed and processed, undergoing multiple maturation steps to form the small (SSU) and large (LSU) ribosomal subunits3,4,5.
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