Lifei Jiang on Muck Rack

Lifei Jiang

As seen in: Nature, Cell Press
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Articles

Deep learning of functional perturbations from condensate morphology

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By Anita Donlic, Troy J. Comi, Sofia A Quinodoz, Nima Jaberi-Lashkari, Krist Antunes Fernandes, Lifei Jiang, Lennard Wiesner, Clifford P. Brangwynne
| Cell Press Verified
Keywords biomolecular condensate high-content imaging deep learning morphological profiling RNA biochemistry nucleolus nuclear speckle RSV TOP1 Introduction Spatial compartmentalization of biomolecular interactions is key to achieving complex cellular functions.
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Mapping and engineering RNA-driven architecture of the multiphase nucleolus - Nature

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By Sofia A Quinodoz, Lifei Jiang, Aya A Abu-Alfa, Troy J. Comi, Qiwei Yu, Lennard Wiesner, Prashant Bhat, Christiane Zorbas, Ludivine Wacheul, Andrej Košmrlj, Sebastian Klinge, Jordy F. Botello
| Nature Verified
Abstract Biomolecular condensates are key features of intracellular compartmentalization1,2. As the most prominent nuclear condensate in eukaryotes, the nucleolus is a multiphase liquid-like structure in which ribosomal RNAs (rRNAs) are transcribed and processed, undergoing multiple maturation steps to form the small (SSU) and large (LSU) ribosomal subunits3,4,5.
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Mapping and engineering RNA-controlled architecture of the multiphase nucleolus

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By Sofia A Quinodoz, Troy J. Comi, Lifei Jiang, Aya A Abu-Alfa
| biorxiv.org
Abstract Biomolecular condensates are key features of intracellular compartmentalization. As the most prominent nuclear condensate in eukaryotes, the nucleolus is a layered multiphase liquid-like structure and the site of ribosome biogenesis. In the nucleolus, ribosomal RNAs (rRNAs) are transcribed and processed, undergoing multiple maturation steps that ultimately result in formation of the ribosomal small subunit (SSU) and large subunit (LSU).
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