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Articles by Leon Ullrich
Pre-existing neutralizing antibodies against cattle-transmitted influenza A virus H5N1 are detectable in unexposed individuals
Keywords influenza virus H5N1 highly pathogenic avian influenza clade 2.3.4.4b A/Texas/37/2024 humoral immunity pre-existing antibodies cross-neutralizing antibodies Introduction Sporadic human infections with highly pathogenic avian influenza A virus (HPAIV) H5N1 were first documented by spillover from birds to humans in 1997, followed by repeated outbreaks among birds with a total of 954 human cases leading to 464 deaths (48.6% case-fatality rate) between 2003 and 2024.1 In March 2024, the...
ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer - Nature Communications
Abstract Small cell lung cancer (SCLC) is characterized by its highly aggressive phenotype and dismal outcome. Despite the benefit of adding immune checkpoint blockade to standard chemotherapy, tumors acquire the ability to evade immunosurveillance and develop resistance. To investigate these underlying mechanisms, we perform high-dimensional profiling of human and murine SCLC specimens.
Detection of low pre-existing humoral immunity against influenza virus H5N1 clade 2.3.4.4b in unexposed individuals
Abstract The repeated spill-over of Influenza A virus H5N1 clade 2.3.4.4b from cattle to humans highlights the risk of a human H5N1 pandemic. Given the impact of pre-existing immunity on the course and severity of viral infections, we assessed in detail the humoral immunity against the H5N1 A/Texas/37/2024 isolate in H5N1-naive individuals. To this end, we performed complementary binding and neutralization assays on 66 subjects and ranked activities among a panel of 76 influenza A virus isolates.
Der Held vom Bahnhof Friedrichstrasse (2025)
Der Held vom Bahnhof Friedrichstrasse erzählt die Geschichte vom kurz vor der Pleite stehenden Berliner Videothekenbesitzer Micha Hartung (Charly Hübner), der ungewollt zum gesamtdeutschen Helden wird: Als ihn zum 30. Jahrestag des Mauerfalls ein Journalist zum Drahtzieher der größten Massenflucht der DDR stilisiert, steht sein Leben plötzlich Kopf. Als Hochstapler wider Willen verstrickt sich Micha in einem Gestrüpp aus Halbwahrheiten und handfesten Lügen.
γδ T cells license immature B cells to produce a broad range of polyreactive antibodies
Method details Flow cytometry Single-cell suspensions from peripheral lymph nodes and spleen were prepared by mechanically meshing the organs through a nylon gaze followed by filtration and lysis of red blood cells. Bone marrow was collected from both femurs and tibias. After removing the ends of each bone, marrow was flushed from cavities using a 25-gauge syringe and FACS buffer (PBS with 3% FCS and 40 mM EDTA).
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