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Leqian Yu on Muck Rack

Leqian Yu

As seen in: Nature, Wiley Online Library, BioRxiv, Cell Press, Cell Stem Cell, Stem Cell Reports, Chemistry World
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Articles

Reconstituting human primitive streak formation through extra-embryonic cell coordination

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By Xin Zhang, Naixin Chen, Xiaodi Yan, Hongan Ren, Xizhuang Sun, Linjie Xu, Jianchao Zhao, Rong Li, Sirui Lin, Xiaojie Jia, Leqian Yu, Yulei Wei, Qiaoyan Shen
| Cell Press Verified
Keywords human development gastrulation embryo model gastruloid extra-embryonic cells extra-embryonic mesoderm cell-cell interaction primitive streak Get full text access Log in, subscribe or purchase for full access. References 1. Arnold, S.J. ∙ Robertson, E.J. Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo Nat. Rev. Mol. Cell Biol. 2009; 10:91-103 2. Peng, G. ∙ Suo, S. ∙ Cui, G. ...
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A three-dimensional spatial transcriptome atlas reconstructs early organogenesis in primate Carnegie stages 9 and 10 embryos

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By Jia Tan, Yifang Liu, Yuting Fu, Yan Wu, Tiantian Guo, Shikai Jia, Yujia Jiang, Tingli Yuan, Jie Li, Yixin Li, Zhi Hao Huang, Shenglong Li, Xixi Yan, Xiaojing Liu, Bowen Hu, Shujie Fu, Shijie Hao, Luyi Tian, Zhen Liu, Leqian Yu, Longqi Liu, Xiaodong Liu, Langchao Liang, Zizhuo Liao
| Nature Verified
Abstract The early organogenesis stage is a critical phase of embryogenesis that lays the foundation for organ development, and is characterized by dynamic and spatially organized transcriptional programs. However, limited spatial transcriptomic information has constrained our understanding of early primate organogenesis.
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3D biomimetic niche modulates embryo development in vitro - Nature Communications

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By Jia Guo, Zili Gao, Tan Jia, Leyun Wang, Jingxi Dong, Zhen Gu, Shen JI, Wei Li, Hongmei Wang, Jinglei Zhai, Leqian Yu, Guihai Feng, Qi Zhou, Jiawei Lyu
| Nature Verified
Abstract Embryo development undergoes critical morphological transformations post-implantation, largely driven by the complex and dynamic microenvironment of the uterus. Despite advances, current 3D culture models inadequately recapitulate the uterine environment necessary for studying embryo-uterus interactions. In this work, we engineer a hydrogel inspired by the properties of the decidua, incorporating Matrigel to support blastocyst implantation and embryo development in vitro.
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