Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Leyun Wang
3D biomimetic niche modulates embryo development in vitro - Nature Communications
Abstract Embryo development undergoes critical morphological transformations post-implantation, largely driven by the complex and dynamic microenvironment of the uterus. Despite advances, current 3D culture models inadequately recapitulate the uterine environment necessary for studying embryo-uterus interactions. In this work, we engineer a hydrogel inspired by the properties of the decidua, incorporating Matrigel to support blastocyst implantation and embryo development in vitro.
Human gastroids to model regional patterning in early stomach development - Nature
Abstract The human stomach features distinct, regionalized functionalities along the anterior–posterior axis1,2. Historically, studies on stomach patterning have used animal models to identify the underlying principles3,4,5,6,7. Recently, human pluripotent stem (hPS)-cell-based gastric organoids for modelling domain-specific development of the fundic and antral epithelium are emerging8,9,10.
Peptide codes for organ-selective mRNA delivery - Nature Materials
Abstract Organ-selective delivery of messenger RNA (mRNA) is critical for fulfilling the therapeutic potential of mRNA-based gene and protein replacement technologies. Despite clinical advances in the hepatic delivery of mRNA using lipid nanoparticles (LNPs), current strategies for extrahepatic-organ-selective mRNA delivery still have limitations.
Leyun Wang - OCT News
August 8, 2025 | General Technology | Peking Union Medical College, The Chinese University of Hong Kong, Xiamen University Optical coherence tomography angiography (OCTA) is a major advancement in imaging, offering high-resolution microvascular volumetric images crucial for diagnosing and studying dermatological diseases.
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos - Nature Structural & Molecular Biology
Abstract The heterogeneity of CARM1 controls first cell fate bias during early mouse development. However, how this heterogeneity is established is unknown. Here, we show that Carm1 mRNA is of a variety of specific exon-skipping splicing (ESS) isoforms in mouse two-cell to four-cell embryos that contribute to CARM1 heterogeneity. Disruption of paraspeckles promotes the ESS of Carm1 precursor mRNAs (pre-mRNAs).
Dine‐in or take‐away? Scavenging strategies in predaceous diving beetles at different water depths
CONFLICT OF INTEREST STATEMENT The authors declare no competing interests. REFERENCES (2023) Dispersal in Dytiscidae. Ecology, Systematics, and the Natural History of Predaceous Diving Beetles (Coleoptera: Dytiscidae) (ed. by DA Yee), pp. 505–528. Springer International Publishing, Cham, Switzerland. & (2019) An army of one: predaceous diving beetle life history stages affect interactions with shared mosquito prey. Hydrobiologia 827: 201–209.
Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging
Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging Xin Li, Jiaqiang Wang, Leyun Wang, Guihai Feng, Gen Li, Meixin Yu, Yufei Li, Chao Liu, Xuewei Yuan, Guangxi Zang, Zhihuan Li, Ling Zhao, Hong Ouyang, Qingli Quan, Guangyu Wang, Charlotte Zhang, Oulan Li, Junkai Xiang, Jian-Kang Zhu, Wei Li, Qi Zhou, Kang Zhang Proceedings of the National Academy of Sciences Feb 2020, 201919403; DOI: 10.1073/pnas.1919403117
SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development
Abstract The oocyte epigenome plays critical roles in mammalian gametogenesis and embryogenesis. Yet, how it is established remains elusive. Here, we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a crucial regulator of the mouse oocyte epigenome.
Cell Press: Cell Press
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Leyun
Contact Leyun, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack