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Articles by Lin Han
Tumor-associated macrophages promote glucose metabolism by driving histone H3 lysine 18 lactylation in glioma progression
Abstract The tumor-associated macrophages (TAMs) play multiple roles in the progression of glioma. However, whether and how TAMs are involved in regulating glucose metabolism in glioma remains unclear.
Combined Bulk and Single-Cell RNA Sequencing Reveals Alterations in the Immune Microenvironment and Candidate Immune-Related Genes Associated With Diagnosis and Relapse in Childhood B-Cell Acute Lymphoblastic Leukemia
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement All data generated or analyzed during this study are included in this published article and its files. Supporting Information Filename Description pbc70741-sup-0001-SuppMat.docx2.2 MB Supporting File 1: pbc70741-sup-0001-SuppMat.docx. pbc70741-sup-0002-SuppMat.xlsx472.4 KB Supporting File 2: pbc70741-sup-0002-SuppMat.xlsx.
Impact of cancer on mortality in critically ill patients with sepsis: a propensity score-matched analysis
Abstract Because cancer may affect sepsis prognosis, yet its association as a comorbidity remains unclear, this study aimed to evaluate the association between pre-existing cancer and mortality in critically ill septic patients. This retrospective cohort study utilized the Medical Information Mart for Intensive Care IV version 3.0 database (2008–2022), focusing on adult ICU patients with sepsis and underlying cancer as the exposure variable.
N-Myc and STAT interactor as a context-dependent switch in innate antiviral immunity
Abstract N-Myc and STAT interactor (NMI), initially identified as a Myc- and STAT-associated protein, is increasingly recognized as a regulatory node in innate antiviral immunity. Current evidence indicates that NMI does not exert a fixed antiviral or proviral effect. Instead, its functional output is shaped by interacting partners, signaling pathway context, subcellular localization, and stage of infection.
A Predictive Model for Mortality in VA-ECMO Patients Based on Early Coagulation-Immune Interactions: A Single-Center Retrospective Study
Keywords Extracorporeal Membrane Oxygenation Mortality Risk Factors Platelet-to-Lymphocyte Ratio Dynamic Monitoring Get full text access Log in, subscribe or purchase for full access. References 1. Combes, A. ∙ Hajage, D. ∙ Capellier, G. ... EOLIA Trial Group, REVA, and ECMONet. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome N Engl J Med. 2018; 378:1965-1975 2. Mendes, P.V. ∙ Melro, LMG ∙ Li, H.Y. ...
Xylt2 Knockout Eliminates O-Xylosylation and Enhances Bone Morphogenetic Protein 2 Production in Chinese Hamster Ovary Cells
L.Han, N.Wu, Q.Li, et al. “Xylt2 Knockout Eliminates O-Xylosylation and Enhances Bone Morphogenetic Protein 2 Production in Chinese Hamster Ovary Cells.” Biotechnology Journal21, no. 6 (2026): e70256. https://doi.org/10.1002/biot.70256 Conflicts of Interest All authors were employees of WuXi Biologics at the time the work was performed.
Clinical heterogeneity and treatment optimization in anti-KLHL11 encephalitis: two case reports and literature review
Abstract Objective: This study aimed to investigate the clinical features, differential treatment responses, and management strategies of encephalitis associated with anti-Kelch-like protein 11 (KLHL11) antibodies. Methods: We report two cases of anti-KLHL11 encephalitis that improved following immunotherapy and present a literature review of cases published in the last six years. Results: Case 1 involved a 52-year-old woman who tested positive for serum anti-KLHL11 antibodies at a 1:100 titer.
Case Report: successful non-surgical management of massive isolated tricuspid Libman-Sacks endocarditis in a pregnant patient with SLE and secondary APS
Abstract Background: Isolated tricuspid valve Libman-Sacks endocarditis (LSE) is extremely rare, and its occurrence during pregnancy with severe thrombocytopenia poses major diagnostic and therapeutic challenges. Case summary: A 21-year-old pregnant woman at 13 weeks of gestation with systemic lupus erythematosus (SLE) and secondary antiphospholipid syndrome (APS) presented with severe thrombocytopenia (platelet count 21 × 109/L).
From Microbes to Molecules: Biodegradable Microplastics Reshape Soil Carbon Metabolism and Composition of Dissolved Organic Matter Click to copy article link Article link copied!
Cite Jump to ExpandCollapse Omics Technologies Applied to Agriculture and FoodMay 13, 2026 From Microbes to Molecules: Biodegradable Microplastics Reshape Soil Carbon Metabolism and Composition of Dissolved Organic Matter Click to copy article linkArticle link copied! Xiaojing Hu Xiaojing Hu State Key Laboratory of Black Soils Conservation and Utilization, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, 138 Haping Road, Harbin 150081, P. R.
Ensemble machine learning algorithms leveraged on serum proteomics for enhanced early detection of ovarian cancer
Abstract Ovarian cancer poses a significant clinical challenge due to its asymptomatic onset and poor prognosis, highlighting the critical need for effective early detection strategies. This study developed a framework that integrates serum proteomic profiling with machine learning algorithms.
Ketogenic diet exacerbates DSS-induced colitis through a β-hydroxybutyrate- Thomasclavelia spiroformis -γδ17 T cell axis in mice
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Abstract Ketogenic diet (KD) is widely recognized for its immunomodulatory and metabolic benefits, but the impact on inflammatory bowel disease remains controversial. Here, we demonstrate that KD maintains homeostasis under physiological conditions but exacerbates colitis by triggering a ketogenesis-microbe-immune cascade upon mucosal injury. Mechanistically, KD elevates luminal β-hydroxybutyrate (β-HB), promoting the expansion of Thomasclavelia spiroformis (T. spiroformis). In turn, T.
By Yameng Liu, Xuan Wu, Li Chen, Shan Wang Verified, Jingyi Xu, Weifeng Wang, Xueting Yao, Wei Xie, Shuai Li, Yueying Li, Lin Han, Cen Xie, Lei Chen, Frank Gonzalez, Weiwei Liu, Xianchun Zhong
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Nature
Verified
Machine learning methods to predict leprosy misdiagnosis in Yunnan Province, People's Republic of China
Abstract Background and objective: Leprosy is a chronic infectious disease caused by Mycobacterium leprae that is often misdiagnosed. This study aimed to identify factors associated with leprosy misdiagnosis and develop and compare machine learning (ML) models to predict the risk of misdiagnosis. Methods: A retrospective analysis was conducted on clinical and epidemiological data in 486 diagnosed leprosy patients.
A deep learning-based IoT malware detection approach for electric vehicle charging stations
Abstract As Electric Vehicle (EV) charging stations become increasingly intelligent, more Internet of Things (IoT) devices are being integrated to improve operational efficiency. Efficient and accurate detection of IoT malware is crucial to ensuring the stable and reliable operation of these charging systems. However, existing research in this field still exhibits three major limitations. First, most existing research lack unified adaptability across multiple CPU architectures.
Uterine Leiomyomas with Intravenous Leiomyomatosis: A Report of Two Cases
Back to Journals » International Journal of Women's Health » Volume 18 Authors Jiang S , Feng Z, Han L Received 10 March 2026 Accepted for publication 24 May 2026 Published 4 June 2026 Volume 2026:18 608143 DOI https://doi.org/10.2147/IJWH.S608143 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Vinay Kumar Shengping Jiang,1,* Zhen Feng,2,* Lin Han3 1Department of Radiology, The First People’s Hospital of...
A conceptual model and study of cross-cultural business relationships
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The impact of metabolic syndrome and triglyceride-glucose index on the risk of in-stent restenosis after percutaneous coronary intervention: a retrospective study
Abstract Background: In-stent restenosis (ISR) remains a significant clinical challenge after percutaneous coronary intervention (PCI). Metabolic syndrome (MetS), characterized by a cluster of metabolic abnormalities, is increasingly recognized as a contributor to cardiovascular disease progression. This study aimed to investigate the association between MetS and the risk of ISR.
Role of Reward Dysregulation in the Association Between Depression and Obesity: A Systematical Review
Disclosure The funding agents had no role in the design and conduct of the study; collection, management, and interpretation of the data; preparation, review, or approval of the manuscript.
Analytical Solution for Coupled Solute Transport and Consolidation Under Semi‐Infinite Conditions and Its Application to Clay Liner Thickness Design
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data are available from the corresponding author upon reasonable request. Supporting Information Filename Description nag70214-sup-0001-SuppMat.zip713 B Supplementary File 1: nag70214-sup-0001-SuppMat.zip References 1, , and , “Municipal Solid Waste-Transforming Waste to Wealth in a Sustainable Manner,” Current Science 127, no. 5 (2024): 527–536, https://doi.org/10.18520/cs/v127/i5/527-536.
Revealing cerebrospinal fluid biomarkers in Parkinson's disease dementia based on iTRAQ proteomics research
Introduction Parkinson's disease (PD) is a common neurodegenerative disorder characterized by an insidious onset and a protracted clinical course. Its primary pathological hallmark is the degeneration of dopaminergic neurons in the substantia nigra pars compacta (Nwabufo and Aigbogun, 2022).
Treatment of T2DM-related inflammation and vascular injury by regulating cellular crosstalk in the islet microenvironment
1 Introduction Type 2 diabetes mellitus (T2DM) comprises 90% of the global diabetes cases, posing severe threats to the life and socioeconomic well-being worldwide (1, 2). In 2021, the International Diabetes Federation (IDF) estimated the global prevalence of diabetes at 537 million individuals. This number is projected to rise to 643 million by 2030 and 783 million by 2045 (3).
Local photocrosslinking of native tissue matrix regulates lung epithelial cell mechanosensing and function - Nature Materials
Abstract Within most tissues, the extracellular microenvironment provides mechanical cues that guide cell fate and function. Changes in the extracellular matrix such as aberrant deposition, densification and increased crosslinking are hallmarks of late-stage fibrotic diseases that often lead to organ dysfunction. Biomaterials have been widely used to mimic the mechanical properties of the fibrotic matrix and study pathophysiologic cell function.
906 Bromton Dr, Westbury, NY 11590, US
Operating Expenses Recurring costs required to maintain and manage a rental property, including property taxes, insurance, maintenance, repairs, utilities (if paid by the owner), property management fees, and other day-to-day expenses. Calculation: Insurance + Property Taxes + Property Management + Repairs & Maintenance + Capital Expenditures + HOA Fees
The postoperative relief of vertigo and migraine in Meniere’s disease patients with and without migraine
Abstract Background The correlation of Meniere’s disease (MD) and migraine remains unclear. Objectives To explore the relation of MD and migraine by analyzing the postoperative relief of vertigo and migraine in MD patients with migraine. Material and methods 104 MD patients were enrolled. The monthly vertigo episodes (MVE) and migraine headache index (MHI) were used for assessing effectiveness at pre- and post-endolymphatic sac decompression (ELSD).
Circle Detection with Adaptive Parameterization: A Bottom-Up Approach
Sensors (Basel, Switzerland). 2025 Apr 17;25(8):2552. doi: 10.3390/s25082552 Q23.42024 Lin Han 1, Yan Zhuang 1, Ke Chen 1, Yuhua Xie 1, Guoliang Liao 1, Guangfu Yin 1, Jiangli Lin 1 作者单位 +展开 作者单位 1 College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.
Targeting FABP4 to Inhibit AGEs‐RAGE/NF‐κB Signalling Effectively Ameliorates Nucleus Pulposus Dysfunction and Angiogenesis in Obesity‐Related Intervertebral Disc Degeneration
1 Introduction Low back pain (LBP) is a common condition, with approximately 80% of people worldwide experiencing symptoms of LBP at some point during their lifetime [1]. Intervertebral disc degeneration (IVDD) is a major contributing factor to LBP [1]. Currently, IVDD cannot be cured, and conservative treatment is mainly used in the early stage of IVDD, including physical therapy, oral medication, lumbar muscle exercise, local nerve blockade, etc [2].
Preparation and Properties of Toughened PLA/PBAT Blends Based on EVA and Multi‐Functional Epoxy Chain Extender
References 1, , , and , “Bio-Based Ethylene-Co-Vinyl Acetate/Poly (Lactic Acid) Thermoplastic Vulcanizates With Enhanced Mechanical Strength and Shape Memory Behavior,” Polymer Testing 87 (2020): 106537. 2, , , , , and , “Design of Biodegradable PLA/PBAT Blends With Balanced Toughness and Strength via Interfacial Compatibilization and Dynamic Vulcanization,” Polymer 266 (2023): 125620.
Multi-Omics Insights into Rumen Microbiota and Metabolite Interactions Regulating Milk Fat Synthesis in Buffaloes
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Barriers to and Facilitators of e‐Learning Health Education Based on the Mental Workload Framework: A Scoping Review
Conflicts of Interest The authors declare no conflicts of interest. References , , , et al. 2020. “Patient Education and Engagement Through Multimedia: A Prospective Pilot Study on Health Literacy in Patients With Cerebral Aneurysms.” World Neurosurgery 138: e819–e826. https://doi.org/10.1016/j.wneu.2020.03.099. , , , , , and . 2017. “Lessons Learned From the Usability Assessment of Home-Based Telemedicine Systems.” Applied Ergonomics 58: 424–434. https://doi.org/10.1016/j.apergo.2016.08.003. 2022.
One‐Dimensional Fully Coupled Hydro‐Mechanical‐Chemical Model for Contaminant Transport Under Step‐Loading Condition and Its Analytical Solutions
Conflicts of Interest The authors declare no conflicts of interest. References 1, , , and , “Analytical Solution of Contaminant Diffusion Through Multi-Layered Soils,” Chinese Journal of Geotechnical 28, no. 4 (2006): 521–524, https://doi.org/10.3321/j.issn:1000-4548.2006.04.018. 2, , , and , “Contaminant Mitigating Performance of Chinese Standard Municipal Solid Waste Landfill Liner Systems,” Geotextiles and Geomembranes 27, no. 3 (2009): 232–239, https://doi.org/10.1016/j.geotexmem.2008.11.007.
Impact of Sintering Aid Type and Content on the Mechanical Properties of Digital Light Processing 3D-Printed Si3N4 Ceramics
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Mass Production of Graphene Oxide Beyond the Laboratory: Bridging the Gap Between Academic Research and Industry
1. Introduction Click to copy section linkSection link copied! Twenty years have passed since the isolation and fundamental properties of graphene were reported. With the recognition of the Nobel Prize in Physics and the advancement of research projects such as Graphene Flagship, graphene has become widely recognized not only in academic circles but also in industry and society.
Conformation‐Controlled Double Phosphorescence Components From A Single Organic Molecule: Time‐Dependent and Excitation‐Dependent Wide‐Range Afterglow Color Change
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202411496-sup-0001-SuppMat.docx2.3 MB Supporting Information References 1a) , , , , , , , , , , , , , Nat. Commun. 2020, 11, 944; b) , , , , , , , , , , Adv. Mater. 2022, 34, 2200544; c) , , , , , , , , , , , , Angew. Chem., Int. Ed. 2023, 63, 202314447; d) , , , , , , ACS Nano 2023, 17, 12895; e) , , , , , , , , , , , , , , , , , , , , , , , , , , Nat. Commun. 2022, 13, 4890.
Conformation‐Controlled Double Phosphorescence Components From A Single Organic Molecule: Time‐Dependent and Excitation‐Dependent Wide‐Range Afterglow Color Change
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202411496-sup-0001-SuppMat.docx2.3 MB Supporting Information References 1a) , , , , , , , , , , , , , Nat. Commun. 2020, 11, 944; b) , , , , , , , , , , Adv. Mater. 2022, 34, 2200544; c) , , , , , , , , , , , , Angew. Chem., Int. Ed. 2023, 63, 202314447; d) , , , , , , ACS Nano 2023, 17, 12895; e) , , , , , , , , , , , , , , , , , , , , , , , , , , Nat. Commun. 2022, 13, 4890.
Research on Optimization of Height Difference of a Precision Horizontal Machining Center
1. Introduction Machine tools play a significant role in manufacturing. Structural design optimization is a crucial approach to improving the performance of machine tools. In today’s economic environment, the machine tool industry continually focuses on enhancing performance while reducing costs, conserving energy, and minimizing environmental impacts [1]. A lot of the work focuses on structural optimization or the lightweight design of components or a holistic machine tool. Shen et al.
In Situ Construction of SnS2@SnO2 Heterostructure for Photo‐Assisted Electrocatalysis of Oxygen Evolution Reaction
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202407659-sup-0001-SuppMat.docx11.6 MB Supporting Information References 1, , , , , , , Nano Energy 2015, 13, 414. 2, , , , , , , , Appl. Catal., B 2014, 150, 74. 3, , , , , , , , Environ. Sci. Technol. 2017, 51, 13372. 4, , , , , , , Adv. Funct. Mater. 2021, 31, 2100553. 5, , , Appl. Catal., B. 2012, 123, 174. 6, , , , , , , , , , , Adv. Energy Mater. 2022, 13, 2202964. 7, , , , , , , , , , , , J.
Analytical Solutions for a Fully Coupled Hydraulic‐Mechanical‐Chemical Model With Nonlinear Adsorption
References 1, , and , “Assessment of Consolidation-Induced Contaminant Transport for Compacted Clay Liner Systems,” Journal of Geotechnical and Geoenvironmental 142, no. 3 (2016): 04015091. 2, , and , “Performance Issues of Barrier Systems for Landfills: A Review,” Geotextiles and Geomembranes 49, no. 2 (2021): 475–488. 3 and , “Assessment of the Landfill Barrier System Through Numerical Analysis: Rehabilitation and Expansion of Belgrade Landfill Case Study,” Sustain 14, no. 13 (2022): 7647.
A Polymer Rigidity Probe Based on Ultralong Organic Room Temperature Phosphorescence of A New Skeleton Benzo[4,5]imidazo[1,2-a]pyridine
A Polymer Rigidity Probe Based on Ultralong Organic Room Temperature Phosphorescence of A New Skeleton Benzo[4,5]imidazo[1,2-a]pyridine Herein, we report a new organic phosphorescence backbone benzo[4,5]imidazo[1,2-a]pyridine (BNPy). BNPy-1 and BNPy-2 are obtained by introducing a benzene ring to each end of BNPy, respectively. BNPy itself shows no ultralong organic room temperature phosphorescence (UORTP) activity.
Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases
Sung A.Y. Floyd B.J. Pagliarini D.J. Systems biochemistry approaches to defining mitochondrial protein function. Cell Metabol. 2020; 31: 669-678https://doi.org/10.1016/j.cmet.2020.03.011 Chemical proteomics to study metabolism, a reductionist approach applied at the systems level. Cell Chem. Biol. 2024; 31: 446-451https://doi.org/10.1016/j.chembiol.2024.02.015 Almeida A. Nayfach S. Boland M. Strozzi F. Beracochea M. Shi Z.J. Pollard K.S. Sakharova E. Parks D.H. Hugenholtz P. et al.
Antiplatelet therapy after coronary artery bypass surgery: five year follow-up of randomised DACAB trial
Research BMJ 2024; 385 doi: https://doi.org/10.1136/bmj-2023-075707 Cite this as: BMJ 2024;385:e075707 Linked Editorial Dual antiplatelet therapy after coronary artery bypass surgery Yunpeng Zhu, associate professor1, Wei Zhang, associate professor2, Arnaldo Dimagli, research fellow3, Lin Han, professor4, Zhaoyun Cheng, professor5, Ju Mei, professor6, Xin Chen, professor7, Xiaowei Wang, professor8, Yanzai Zhou, resident1, Qing Xue, associate professor4, Junlong Hu, attending physician5, Min...
In‐Situ Growth of MgO@rGO Core‐Shell Structure via CO2 Thermal Reaction for Enhanced Photocatalytic Performance
1 Introduction Various industrial activities worldwide are constantly generating wastewater containing potentially toxic and environmentally harmful compounds. The severity of the threat posed by these toxic compounds to human health and the environment is progressively increasing.[1, 2] Organic dyes widely employed in industries such as textiles, printing, food, plastics, and leather exhibit high water solubility, making them prone to dispersion in aquatic environments.
Trend and equity in maternal and child health resource allocation in C
Yuanna Zhou,* Lin Han,* Wuxing Zhang, Yujun Fan, Wenjian Liu, Muzi Liu, Yishan Fan, Xiaoyuan Qu* School of Nursing and Health, Henan University, Kaifeng, Henan, People’s Republic of China *These authors contributed equally to this work Correspondence: Xiaoyuan Qu, School of Nursing and Health, Henan University, Jinming Avenue, Kaifeng City, Henan Province, People’s Republic of China, Email [email protected] Purpose: China has made considerable efforts to promote the...
Impact of Various Ration Energy Levels on the Slaughtering Performance, Carcass Characteristics, and Meat Qualities of Honghe Yellow Cattle
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Design and Experiment of Plate Taking Control System of Edible Sunflower (Edulis Helianthus Catino L.) Harvester
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Bile salt hydrolase activity‐based probes for monitoring gut microbial bile acid metabolism
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description cbic202300821-s1-SI.pdf5.7 MB Supplementary
Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases
Abstract The gut microbiome possesses numerous biochemical enzymes that biosynthesize metabolites that impact human health. Bile acids comprise a diverse collection of metabolites that have important roles in metabolism and immunity. The gut microbiota-associated enzyme that is responsible for the gateway reaction in bile acid metabolism is bile salt hydrolase (BSH), which controls the host's overall bile acid pool.
Microinterfaces in biopolymer-based bicontinuous hydrogels guide rapid 3D cell migration - Nature Communications
Abstract Cell migration is critical for tissue development and regeneration but requires extracellular environments that are conducive to motion. Cells may actively generate migratory routes in vivo by degrading or remodeling their environments or instead utilize existing extracellular matrix microstructures or microtracks as innate pathways for migration.
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