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Lina Wang

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Articles

High ambient temperature activates a neural circuit for gut glucose uptake in male mice

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By Ruihua Li, Mingming Liu, Zhiqi Zhang, Qin Zhu, Mingsi Chen, Jiaxin Liu, Linghui Pan, Qian Zhou, Zuohua Liu, Ruifan Wu, Songbo Wang, Lina Wang, Gang Shu, Pingwen Xu, Qingyan Jiang, Canjun Zhu, Aru Su, Renli Qi
| Nature Verified
Abstract Heat stress triggers defensive energy demands to prevent cellular damage. Using male mice, we found that exposure to high ambient temperature (HAT) induces an increase in intestinal glucose absorption mediated by sodium/glucose cotransporter 1 (SGLT1). Glucose supplementation alleviated HAT-induced physiological damage in mice. Mechanistically, we found that blocking intestinal vagal motor nerve transmission eliminated HAT’s stimulatory effects on intestinal glucose absorption.
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Hesperidin suppressed high-fat diet induced obesity via modulating ROS/JNK/BRD4/SHP2 signaling induced lipogenesis

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By Qi Xie, Shaohua Zhang, Jin Zhao, Lina Wang, Dandan Guo, Lingling Cheng, Yuping Chang, Tengteng Zhou
| Nature Verified
Abstract To investigate the effects of hesperidin on adipogenesis and the ROS/JNK/BRD4/SHP2 signaling pathway in High-Fat Diet (HFD)-induced obese rats, and to explore the potential mechanisms by which hesperidin promotes white adipose browning in obese rats. We obtained high-throughput sequencing datasets of normal-weight individuals and obese patients from the GEO database and performed bioinformatics analysis.
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DPP-4 inhibitors in drug-resistant epilepsy: a hypothesized mechanism via the gut microbiota-short-chain fatty acids-glucagon-like peptide-1 axis

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By Yinyin Xie, Yi Xie, Aoya Han, Xinru Zhou, Shijie Zhang, Changchang Shen, Yuxuan Zhang, Lina Wang, Xili Fu, Nanchang Xie
| Frontiers in Immunology
Abstract Background: Drug-resistant epilepsy (DRE) affects approximately one-third of patients with epilepsy and remains a major therapeutic challenge.Recent studies have demonstrated significant gut microbiota dysbiosis in patients with DRE, and certain interventions targeting the gut microbiota demonstrate therapeutic efficacy. However, pharmacological interventions that precisely modulate the gut microbiota in DRE have not yet been fully explored.
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