Lingying Wu
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SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in advanced solid tumors (HORIZON-X): a global phase 1 trial
Abstract SHR-A1811, an antibody‒drug conjugate consisting of the anti-HER2 antibody trastuzumab conjugated via a cleavable linker to a topoisomerase I inhibitor payload, demonstrated substantial antitumor activity in patients with heavily treated HER2-expressing or mutated advanced solid tumors. The main analysis was reported, and this is a long-term follow-up of the HORIZON-X trial (NCT04446260).
Baishaoluoshi Decoction Mitigates Post‐Stroke Spasticity by Targeting Synaptic Plasticity Through the Nogo‐A/NgR Signaling Pathway
1 Introduction Post-stroke spasticity (PSS), a common motor and sensory disorder that occurs at various stages after a stroke, represents a major clinical challenge in neurorehabilitation (Chen et al. 2025). As the most prevalent type of cerebrovascular accident, cerebral infarction induces upper motor neuron damage, characterized by intermittent or persistent increases in hypertonic stretch reflexes and tendon hyperreflexia (Bavikatte et al. 2021).
Green Preparation of Microcellular Poly(Butylene Adipate‐co‐Terephthalate)/Polyether Block Amides@Multi‐Walled Carbon Nanotube Piezoresistive Sensor with Ultrahigh Strain/Stress Sensitivity
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adem202500210-sup-0001-SuppData-S1.pdf429.2 KB Supplementary Material References 1, , , , , , , , , , , Mater. Des. 2024, 239, 112782. 2, , , , , , , Chem. Eng. J. 2024, 485, 149817. 3, , , , Sens. Actuators, A 2024, 379, 115970. 4, , , , , , , , , ACS Appl. Mater. Interfaces 2024, 16, 66543. 5, , , , , , Chem. Eng. J. 2024, 482, 148988. 6, , , Acc. Mater. Res. 2025, 6, 114. 7, , , , , , Mech. Syst.
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