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Yingbin Liu on Muck Rack

Yingbin Liu

As seen in: Nature, Wiley Online Library, ScienceDirect, Frontiers, MDPI, Taylor & Francis Online, ACS Publications, Cell Press
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Articles

Repetitive superposition performance of stress waves in control module of projectile under dynamic impact

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By Liqing Song, Jianping Yin, Yingbin Liu, Bing Hou, Zhiqiang Fan
| Nature Verified
Abstract During projectile launch or penetration, the control module (CM), as the brain of projectile, endures high dynamic impact, yet stress wave analysis in CM protection remains limited. This paper develops a self-designed projectile-control module device instrumented with polyvinylidene fluoride (PVDF) sensors placed at the front, middle, and rear sections of epoxy resin (EP) in the CM cavity for quantitative stress wave measurement.
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Bacteroides fragilis toxin promotes gall bladder cancer in mice

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By jun chen, Siyuan Kang, Haoyan Liu, Peng Pu, Xiaoling Song, Yingbin Liu, Jingjing Qi, Wenguang Wu, Aiyanlun Tong, Zisong Xu
| Nature Verified
Abstract Enterotoxigenic Bacteroides fragilis (ETBF), which secretes B. fragilis toxin (BFT) and has been associated with colorectal cancer, can be enriched in patients with gall bladder cancer (GBC). Whether and how ETBF contributes to GBC is unclear. Here we confirm, through analysis of patient samples, that ETBF is enriched in GBC tumours, while experiments in mice show that ETBF colonizes the gall bladder. In vitro and in patient-derived organoids, ETBF promoted GBC proliferation.
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Rational design of a Kappa opioid receptor peptide agonist with attenuated β-arrestin signaling

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By Huanhuan Zhang, Ruolan Wang, Pan Shi, Qingjun Zhu, Xinheng He, Youwei Xu, Qingning Yuan, Wen Hu, Kai Wu, Yong Zheng, Li Zhou Verified, Jun Liang, Pei Lv, Ziyan Xu, Fan Yang, Yingbin Liu, Youwen Zhuang, H. Xu, YUE WANG, Changlin Tian, Gaoming Wang
| Nature Verified
Abstract Difelikefalin is an FDA-approved κ-opioid receptor (KOR) peptide agonist used to treat chronic pruritus. However, as a balanced agonist that activates both G protein and β-arrestin pathways, difelikefalin remains associated with undesirable side effects linked to β-arrestin signaling. Here, we report the cryo-EM structure of the difelikefalin-KOR-Gi complex, identifying Y3207.43 as a key residue that is critical for signaling bias.
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