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Liying Yan on Muck Rack

Liying Yan

As seen in: Environmental Health Perspectives, Nature, PLOS, Frontiers, MDPI, Cell Press, Reproductive BioMedicine Online
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Articles

Ypel5 preserves female fertility by regulating folliculogenesis and oocyte maturation

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By Qianying Guo, Yao Li, Fanqing Xu, Qiang Liu, Ying Kuo, Jie Qiao, Peng Yuan, Liying Yan, Shaogang Qin
| Nature Verified
Abstract Maintaining the primordial follicle pool and precisely regulating folliculogenesis are critical for female fertility. Despite advances in understanding ovarian development, the molecular mechanisms safeguarding follicle survival and oocyte maturation remain incompletely defined. Here, we identify YPEL5 as an essential regulator of folliculogenesis and oocyte development.
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Uridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice

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By Jingyue Chen, Jianing Shen, Dongxu Li, Guangjun Huang, Rui Wang, Xiaofan Sun, Meijie Chen, Tianyi Liao, Liying Yan, Peng Yuan, Bo Xiong, Jie Qiao
| Nature Verified
Abstract Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging remain unclear. Here, we show that uridine levels in the plasma and ovaries of aged mice are significantly reduced compared with young controls.
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Single-oocyte full-length isoform sequencing unveils the impact of transposable elements on RNA diversity and stability

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By Yuqian Wang, Wei Wang, Yujun Liu, Yiming He, Hongyu Song, Ming Yang Verified, Nan Wang, Xiaomeng Wang, Ying Kuo, Yuwen Xiu, Zhengrong Du, LU CHEN, Ying Lian, Qiang Liu, Liying Yan, Jie Qiao, Peng Yuan
| Nature Verified
Abstract Oocyte-specific isoforms play crucial roles in oocyte maturation, while current understanding of the oocyte transcriptome is mainly focused on gene level. Here, we utilize single-cell full-length isoform sequencing to detect entire transcripts in human and mouse oocytes. Isoform diversity during oocyte maturation is systematically profiled, including 7154 and 4875 putative novel human and mouse transcripts, respectively.
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