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Ying Kuo

As seen in: Nature, Reproductive BioMedicine Online
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Articles

Ypel5 preserves female fertility by regulating folliculogenesis and oocyte maturation

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By Qianying Guo, Yao Li, Fanqing Xu, Qiang Liu, Ying Kuo, Jie Qiao, Peng Yuan, Liying Yan, Shaogang Qin
| Nature Verified
Abstract Maintaining the primordial follicle pool and precisely regulating folliculogenesis are critical for female fertility. Despite advances in understanding ovarian development, the molecular mechanisms safeguarding follicle survival and oocyte maturation remain incompletely defined. Here, we identify YPEL5 as an essential regulator of folliculogenesis and oocyte development.
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Single-oocyte full-length isoform sequencing unveils the impact of transposable elements on RNA diversity and stability

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By Yuqian Wang, Wei Wang, Yujun Liu, Yiming He, Hongyu Song, Ming Yang Verified, Nan Wang, Xiaomeng Wang, Ying Kuo, Yuwen Xiu, Zhengrong Du, LU CHEN, Ying Lian, Qiang Liu, Liying Yan, Jie Qiao, Peng Yuan
| Nature Verified
Abstract Oocyte-specific isoforms play crucial roles in oocyte maturation, while current understanding of the oocyte transcriptome is mainly focused on gene level. Here, we utilize single-cell full-length isoform sequencing to detect entire transcripts in human and mouse oocytes. Isoform diversity during oocyte maturation is systematically profiled, including 7154 and 4875 putative novel human and mouse transcripts, respectively.
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Clinical outcomes of complex chromosomal rearrangements carriers and couples both harboring chromosomal rearrangements who undergo preimplantation genetic testing

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By Zhengxin Lyu, Yun Wang, Xiaohui Zhu, Ying Kuo, Shuo Guan, Liying Yan, Yuan Wei, Jie Qiao, Zhiqiang Yan
| Reproductive BioMedicine Online Verified
1State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital Beijing 100191, China 2National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China 3Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China 4Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive...
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