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Longying Jiang on Muck Rack

Longying Jiang

As seen in: Nature, Cell Press, The Journal of Biological Chemistry
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Articles

A Hybrid compound H93 treats prostate cancer by directly binding UHRF1 and promoting protein dimerization - Communications Chemistry

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By Yuxin Fu, Longying Jiang, Yongheng Chen
| Nature Verified
Abstract UHRF1 is a pivotal epigenetic regulator bridging DNA methylation and histone modifications, frequently overexpressed in prostate cancer (PCa). However, no UHRF1-targeted therapeutics have advanced to clinical trials. Here, we report the development of H93, a hybrid small molecule integrating functional groups derived from NSC232003 and vorinostat, respectively.
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Structural characterization of the DNA binding mechanism of retinoic acid-related orphan receptor gamma

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By Longying Jiang, Xueke Liu, Xujun Liang
| Cell Press Verified
De Bosscher K. Desmet S.J. Clarisse D. Estébanez-Perpiña E. Brunsveld L. Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation. Nat. Rev. Endocrinol. 2020; 16: 363-377 Khorasanizadeh S. Rastinejad F. Visualizing the Architectures and Interactions of Nuclear Receptors. Endocrinology. 2016; 157: 4212-4221 Frigo D.E. Bondesson M. Williams C. Nuclear receptors: from molecular mechanisms to therapeutics. Essays Biochem.
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Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity - Nature Communications

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By Hudie Wei, Longying Jiang, Youjun Li, Ming Guo
| Nature Verified
Abstract Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle network of protein interactions. The tumor suppressor protein p53 triggers transcription-independent apoptosis through direct interactions with BCL-2 family proteins, but the molecular mechanism is not well understood. In this study, we present three crystal structures of p53-DBD in complex with the anti-apoptotic protein BCL-2 at resolutions of 2.3–2.7 Å.
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