Lu Yin
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Quantum-sensing-based super-resolution live cell microenvironment imaging
Abstract Direct monitoring the multifaceted intracellular microenvironment is fundamental for deciphering localized cellular behavior and function. However, performing nanoscale spatiotemporal sensing of the dynamic physiochemical environment within a live cell has remained challenging, mainly limited by the lack of robust, biocompatible method which satisfies the requirements for spatiotemporal resolution, sensitivity, multi-physical sensing capability and long-term viability.
An mPFC–DMV cortical–autonomic–immune axis governs stress-induced immune dysregulation in sepsis
Abstract Chronic psychological stress is a major predisposing factor that worsens sepsis outcomes, yet the neural mechanisms linking stress exposure to immune dysregulation remain poorly understood. Here, using a mouse model of chronic restraint stress (CRS) followed by endotoxemia, we show that prior stress markedly aggravates mortality, systemic inflammation, and immune imbalance during sepsis.
Drillability-informed ROP prediction and parameter optimization in complex formations
Abstract Rate of penetration (ROP) is a key indicator of drilling efficiency in complex formations and directly affects drilling time and cost. Under heterogeneous geological conditions, variations in formation drillability and mismatches between drilling parameters and formation characteristics can reduce rock-breaking efficiency and constrain ROP. This study develops a drillability-informed framework integrating formation characterization, ROP prediction, and drilling parameter optimization.
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