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Luan Le

As seen in: Cell Press, The Journal of Clinical Investigation

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Articles

Reduced thymic IL-4 impairs negative T cell selection in nonobese diabetic mice

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By Alexis N. Cattin-Roy, Kimberly G. Laffey, Luan Le, Adam G Schrum
| The Journal of Clinical Investigation
Abstract Type 1 diabetes (T1D) develops spontaneously despite functional antigen presentation machinery in the thymus and a perceptible central tolerance process.
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Bridging Ribosomal Synthesis to Cell Growth through the Lens of Kinetics

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By Luan Le, Nanyang Technological, Kaicheng Zhu
| Cell Press Verified
The quantitative comprehension of the prokaryotic cell growth requires a multi-scale modeling framework from a kinetics perspective. Cells regulate protein synthesis in response to nutrient conditions for fastest growth. In vitro biochemical experiments reveal the detailed kinetics pathway of ribosomes beyond the scope of the kinetics model of Hopfield.
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