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Lugard Sichalwe

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Articles

Multi-site wastewater metagenomics reveals geographically distinct microbial communities and plasmid-mediated antimicrobial resistance co-selection in Zambia

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By Charlie C. Luchen, Marlon Banda, Jay Sikalima, Innocent Mwape, Kennedy Chibesa, Noah Hull, Chipo Mambo, Mwelwa Chibuye, Precious Simushi, Suwilanji Silwamba, Michael Njuguna, Fatim Jallow, Dhally M. Menda, Victor Daka, Caroline C. Chisenga, Michelo Simuyandi, Samuel Bosomprah, Doreen M. Shempela, Walter Muleya, Paul Simusika, Karen Sichinga, Edgar Simulundu, Roma Chilengi, Dickson Sandala, Mapeesho Kamayani, Mike Masona, Ben Katowa, Keith Kabengele, Lugard Sichalwe, Clement Phiri, Ephraim Chandela, Chilufya Mulenga, Michael Kachumi
| Nature Verified
Abstract Antimicrobial resistance (AMR) poses a disproportionate burden in low- and middle-income countries, yet comprehensive environmental surveillance, particularly for plasmid-mediated resistance, remains critically limited in sub-Saharan Africa. Wastewater systems harbour diverse microbial communities with a high potential to mobilise antibiotic resistance genes (ARGs), thereby driving the environmental dissemination of resistance.
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