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Mwelwa Chibuye on Muck Rack

Mwelwa Chibuye

As seen in: Nature, PLOS Medicine, Frontiers in Immunology
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Articles

Multi-site wastewater metagenomics reveals geographically distinct microbial communities and plasmid-mediated antimicrobial resistance co-selection in Zambia

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By Charlie C. Luchen, Marlon Banda, Jay Sikalima, Innocent Mwape, Kennedy Chibesa, Noah Hull, Chipo Mambo, Mwelwa Chibuye, Precious Simushi, Suwilanji Silwamba, Michael Njuguna, Fatim Jallow, Dhally M. Menda, Victor Daka, Caroline C. Chisenga, Michelo Simuyandi, Samuel Bosomprah, Doreen M. Shempela, Walter Muleya, Paul Simusika, Karen Sichinga, Edgar Simulundu, Roma Chilengi, Dickson Sandala, Mapeesho Kamayani, Mike Masona, Ben Katowa, Keith Kabengele, Lugard Sichalwe, Clement Phiri, Ephraim Chandela, Chilufya Mulenga, Michael Kachumi
| Nature Verified
Abstract Antimicrobial resistance (AMR) poses a disproportionate burden in low- and middle-income countries, yet comprehensive environmental surveillance, particularly for plasmid-mediated resistance, remains critically limited in sub-Saharan Africa. Wastewater systems harbour diverse microbial communities with a high potential to mobilise antibiotic resistance genes (ARGs), thereby driving the environmental dissemination of resistance.
Open in Who Shared Issue with article?

Pre-vaccination biomarkers of enteric dysfunction, inflammation and nutritional status associate with seroconversion to oral cholera vaccine and are perturbed during natural infection

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By Fraser Liswaniso, Bernard J Phiri, Mwelwa Chibuye, Charlie C. Luchen, Kennedy Chibesa, Mutinta Muchimba, Roma Chilengi, Samuel Bosomprah, Caroline C. Chisenga, Dennis Ngosa
| Frontiers in Immunology
Abstract Background: Oral cholera vaccines (OCVs) show variable immunogenicity in endemic settings. Host factors including enteric dysfunction, systemic inflammation, and nutritional status may influence responses, yet their role in shaping OCV immune responses is not fully understood.
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Systematic review of associations between gut microbiome composition and stunting in under-five children - npj Biofilms and Microbiomes

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By Mwelwa Chibuye, Daniel R. Mende, Michelo Simuyandi, Chaluma C. Luchen
| Nature Verified
Abstract Childhood stunting is associated with impaired cognitive development and increased risk of infections, morbidity, and mortality. The composition of the enteric microbiota may contribute to the pathogenesis of stunting. We systematically reviewed and synthesized data from studies using high-throughput genomic sequencing methods to characterize the gut microbiome in stunted versus non-stunted children under 5 years in LMICs. We included 14 studies from Asia, Africa, and South America.
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