Luke Maggs

ReviewOnline nowOpen access 1Conservation Science Group, Department of Zoology, Cambridge University, The David Attenborough Building, Cambridge, CB2 3QZ, UK 2BirdLife International, David Attenborough Building, Cambridge, CB2 3QZ 3National Trust, Heelis, Swindon, SN2 2NA, UK 4The Wildlife Trusts, The Kiln, Newark, NG24 1WT, UK 5Natural England, Eastbrook, Cambridge, CB2 8DR, UK 6Environment Agency, Horizon House, Bristol, BS1 5AH, UK 7Darwin-Hamied Centre, Christ’s College, Cambridge, CB2...

Keywords: TBK1 CAR-T cells immunotherapy PDOTS solid tumors Disclaimer As a service to authors and researchers we are providing this version of an accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proofs will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to these versions also.

Implications of High Tumor Burden on Chimeric Antigen Receptor T-Cell Immunotherapy: A Review Abstract Importance Chimeric antigen receptor (CAR) T-cell therapy has redefined the therapeutic landscape of several hematologic malignant tumors. Despite its clinical efficacy, many patients with cancer experience nonresponse to CAR T-cell treatment, disease relapse within months, or severe adverse events.