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Luxian Lv

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Articles

Shared genetic architecture of schizophrenia and Alzheimer’s disease and related dementias implicates 16p11.2 and lifespan brain vulnerability

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By Yu Chen, Qi Wang, Qing Liu, Wenqiang Li, Chuansheng Wang, Luxian Lv, Weihua Yue
| Nature Verified
Abstract Epidemiological and clinical observations linking schizophrenia (SCZ) to increased dementia risk, together with the occurrence of psychosis in Alzheimer’s disease and related dementias (ADRD), suggest that shared genetic liabilities may contribute to their co-occurrence.
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Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery - Nature Neuroscience

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By Chu-Yi Zhang, Li Hui, Yuan Z. Gao, Xiaoyang Feng, Yong Wu, Simeng Ma, YaoYao Sun, Yaoyao Sun, Yongfeng Yang, Luxian Lv, Dongsheng Zhou, Chen Zhang, jun chen, Jinsong Tang, Yong-Gang Yao, Chuang Wang, Nakao Iwata, Weihua Yue, Yiru Fang, Feng Zhu, Xiao Xiao
| Nature Verified
Abstract Genome-wide association studies (GWASs) of bipolar disorder (BD) have predominantly included individuals of European (EUR) ancestry, underrepresenting non-EUR populations and limiting insight into disease mechanisms.
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Identification of 1q25.2 as a novel shared locus between schizophrenia and major depressive disorder in east Asians by integrative analyses - Translational Psychiatry

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By Chuyi Zhang, Yongfeng Yang, Ming Li, Luxian Lv, Xiao Xiao
| Nature Verified
Abstract Schizophrenia (SZ) and major depressive disorder (MDD) share psychopathological features, and their overlapped genetic architectures have been well-studied in Europeans. However, the extent of their polygenic overlap in East Asians remains unclear. Genome-wide association study (GWAS) datasets present a valuable resource for exploring this question. We applied linkage disequilibrium score (LDSC) regression and MiXeR analyses to assess polygenic overlap.
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