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YaoYao Sun

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Articles

Calcium signaling pathway implicates a shared genetic basis between psychiatric and cardiovascular diseases

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By Yunqing Zhu, Guorui Zhao, Yuyanan Zhang, Zhe Lu, Zhewei Kang, Xiaoyang Feng, Yundan Liao, Junyuan Sun, Rui Yuan, Jing Guo, Bing Liu, YaoYao Sun, Yaoyao Sun, Weihua Yue
| Nature Verified
Abstract Psychiatric and cardiovascular diseases (CVDs) are frequently comorbid and are interconnected through the brain-heart axis. However, the underlying shared genetic etiology remains unknown in East Asians.
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Genome-wide pleiotropic analysis identifies shared genetic architecture within the cognition–immune nexus

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By Tong Yu, Guorui Zhao, Yuyanan Zhang, YaoYao Sun, Yaoyao Sun, Zhe Lu, Rui Yuan, Yunqing Zhu, Zhewei Kang, Xiaoyang Feng, Junyuan Sun, Jing Guo, Weihua Yue
| Nature Verified
Abstract Increasing evidence supports associations between cognitive function and autoimmune disorders, yet the underlying genetic mechanisms remain unclear. Using large-scale genome-wide association statistics for seven cognitive traits and fifteen autoimmune disorders, together with two independent cohorts comprising 522 healthy individuals and 80 patients with schizophrenia, we performed multi-level pleiotropic analyses.
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Speech as a biomarker for supported diagnosis of major depressive disorder using self-supervised representations

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By Yunhan Lin, Biman Najika Liyanage, Chuan Shi, Zhengwen Zhu, Yutao Sun, YaoYao Sun, Yaoyao Sun, Ziwei Zhang, Jun Yang, Chenyang Xu, Yundan Liao, Yanbao Tao, Zongfeng Li, Guorui Zhao, Weihua Yue
| Nature Verified
Abstract The diagnosis of major depressive disorder (MDD) urgently requires objective biomarkers for clinical translation. In this study, we established a multicenter cohort to date (N = 1,816; comprising 910 MDD patients and 906 healthy control subjects), using 23,608 standardized speech samples. Based on 6,373 acoustic-prosodic features, we develop a deep learning framework that employs a self-supervised architecture to leverage speech biomarkers.
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