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YaoYao Sun

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Articles

Dissecting the shared genetic architecture and biological mechanisms linking sleep traits and suicide attempts: from variants to genes

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By Yajing Xu, YaoYao Sun, Yaoyao Sun, Yuying Li, Suhua Chang, Jianyu Que, Xikun Han, Catharina Lavebratt, Jia Liu, Yan’e Lu
| Nature Verified
Abstract Comorbidities and genetic correlations between sleep traits and suicide attempts suggest potential shared genetic architecture, but pleiotropic genetic variants and functions remain unclear. This study aimed to identify shared genetic variants, genes, and biological mechanisms linking sleep traits with suicide attempts. We conducted a genome-wide pleiotropic analysis using GWAS summary statistics for 11 sleep traits and suicide attempts.
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Higher frequencies of CNV deletions in bipolar disorder among Chinese Population

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By Yong Wu, Xiangyu Li, YaoYao Sun, Yaoyao Sun, Chuyi Zhang, Ping Sun, Li Hui, Ying Zhao, Xiaoyang Feng, Baokun Wang, Jianzhong Yang, Nan Zhang Verified, Jing Yuan, Hongyan Jiang, Yuqi Cheng, Simeng Ma, Qian Gong, Yongfeng Yang, Wenqiang Li, Luxian Lv, Dongsheng Zhou, Xingxing Li, Xiaogang Chen, Chen Zhang, Xueqin Song, Wenxin Tang, Zhongchun Liu, Yongyong Shi, Xiao Xiao, Weihua Yue, Zhiqiang Li, Ming Li, Xuyuan Yin
| Nature Verified
Abstract Although copy number variants (CNVs) represent well-established genetic contributors to schizophrenia (SCZ), their role in bipolar disorder (BD), especially within non-European ancestries, has been inadequately explored. We evaluated the genome-wide load of rare CNVs, encompassing deletions and duplications, in a Han Chinese sample of 3915 BD cases and 7820 ethnically matched controls.
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Calcium signaling pathway implicates a shared genetic basis between psychiatric and cardiovascular diseases

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By Yunqing Zhu, Guorui Zhao, Yuyanan Zhang, Zhe Lu, Zhewei Kang, Xiaoyang Feng, Yundan Liao, Junyuan Sun, Rui Yuan, Jing Guo, Bing Liu, YaoYao Sun, Yaoyao Sun, Weihua Yue
| Nature Verified
Abstract Psychiatric and cardiovascular diseases (CVDs) are frequently comorbid and are interconnected through the brain-heart axis. However, the underlying shared genetic etiology remains unknown in East Asians.
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