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Madison Pilon

As seen in: Nature
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Articles

Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival

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By Lotte Brückner, Robin Xu, Jun Tang, Aditi Gnanasekar, Alexander M. Herrmann, Shu Zhang, Fengyu Tu, Alexander Kukalev, Olga Sidorova, Qinghao Yu, Davide Pradella, Marco Novais-Cruz, Denise Treue, Nadine Wittstruck, Martina Fasciolo Fernandez, Finnja Becker, Xiaowei Yan, Rachel Schmargon, Jan Dörr, David Gamlin, Annika Lehmann, Dennis Gürgen, Matthias Richter, Frank Dubois, Fabrizio Simeoni, Betheney R. Pennycook, Alastair Hamilton Verified, Courtney Dawes, Gabriel Balmus, Barbara Hero, Matthias Fischer Verified, Vineet Bafna, Roel G. W. Verhaak, Geoffrey M. Wahl, Yang Liu Verified, Richard P. Koche, Stamatis Papathanasiou, René H. Medema, Bastiaan Spanjaard, Andrea Ventura, Ana Pombo, Weini Huang, Monika Scheer, Benjamin Werner, Howard Chang, Paul S. Mischel, Anton G. Henssen, Madison Pilon, Katharina Pardon, Joshua Atta, Giulia Montuori, Mila Ilić, Kentaro Suina, Sarah Kaltenbach, Sergej Herzog, Ann-Sophie Hollinger, Nicole Wolozyn, Varvara-Rigina Louma, Ralph K. Lindemann
| Nature Verified
Abstract Extrachromosomal DNA (ecDNA) contributes to cancer genome instability by enabling high-copy oncogene amplification and genetic intratumoral heterogeneity. Micronuclei (MNs) are common in chromosomally unstable cancers, yet their role in ecDNA-driven tumors remains unclear. Here we investigate how ecDNA damage, mitotic segregation and MN formation are linked. We find that ecDNAs are a major source of MNs following their damage, particularly under replication stress.
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