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Malcolm McDonald

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Articles

GABA shapes GBM immune responses in a sex-dependent manner

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By Malcolm McDonald, Benjamin Deneen
| Nature Verified
Glioblastoma is a deadly primary brain tumor with a complex immunosuppressive microenvironment that poses a therapeutic challenge. A study now demonstrates that GABAB signaling enhances immunosuppressive programs of myeloid-derived suppressor cells in female models of preclinical glioblastoma.
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"Tumor-Specific Polycistronic miRNA Delivered by Engineered Exosomes fo" by Malcolm F McDonald, Anwar Hossain et al.

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By Malcolm McDonald
| Texas Medical Center
Abstract Background: Glioblastoma (GBM) has poor prognosis due to ineffective agents and poor delivery methods. MicroRNAs (miRs) have been explored as novel therapeutics for GBM, but the optimal miRs and the ideal delivery strategy remain unresolved.
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What Makes for Healthy Ageing in the Torres Strait?

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By Chenoa Wapau, Malcolm McDonald, Fintan Thompson, Rachel Quigley
| Wiley Online Library Verified
What is already known about this topic? ○ Research with First Nations Peoples has traditionally taken a deficit discourse, which fails to celebrate the strengths within communities that can be harnessed to promote ageing well. ○ This includes measures of Healthy Ageing, based on mainstream indices, which are not always appropriate for Indigenous populations. What this paper adds? ○ A new Torres Strait-focused healthy ageing index has been developed.
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See all 25 licensed articles (26 Total)