Man Wu
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Articles by Man Wu
Real-world user interactions with large language models for explaining home electrocardiogram reports
Abstract With the development of portable electrocardiogram (ECG) devices, users can conveniently obtain physiological data in home settings, yet they still face an interpretation gap because of limited medical knowledge. Large language models (LLMs) may help bridge this gap through natural-language explanations, but large-scale real-world evidence on how users interact with them in home settings remains limited.
Undergraduate nursing students' clinical adaptation: a qualitative journey mapping study from student and clinical preceptor perspectives
Abstract Background: Clinical adaptation is shaped by students' readiness, precepting arrangements, patient responses, and ward conditions. Previous studies have usually examined student and preceptor experiences separately. This study aimed to explore undergraduate nursing students' adaptation to clinical practice from student and clinical preceptor perspectives and to identify key touchpoints, differences in focus, and support needs through journey mapping.
Evolving kinship networks of population-hollowing villages within rapid urbanization: the Liangshan area in China as the case
Abstract Addressing the challenges of rural revitalization in the context of rapid urbanization—including the population decline, insufficient infrastructure, and the disintegration of kinship networks of ethnic minority villages—is essential for achieving sustainable rural development. This paper studied Yubu Village, an ethnic Yi community in China’s Liangshan Yi Autonomous Prefecture, with the aim of investigating the spatiotemporal evolution and reconstruction of its kinship networks.
Deletion of activating transcription factor 3 (Atf3) promotes cardiomyocyte differentiation from embryonic stem cells
Abstract Myocardial infarction is associated with massive cardiomyocyte loss, and embryonic stem cells (ESCs), owing to their cardiomyocyte differentiation ability, have emerged as a promising therapy. One potential factor involved in regulating ESC-to-cardiomyocyte differentiation is activating transcription factor 3 (Atf3), and this study clarifies its involvement. Atf3 was knocked out (ko) in mouse ESCs (mESCs) with CRISPR/Cas9.
Risk factors for diabetic at-risk foot disease among the diabetes over 60 years old: a cross-sectional study
Abstract Background: Most studies related to at-risk foot are based on databases, cohorts, hospitalized patients, or outpatient studies, lacking comprehensive data on risk factors. According to the latest Diabetic foot risk stratification system, there is currently a lack of research or descriptions of the diabetic at-risk foot population.
Nonlinear Interaction with LLMs: Enhancing Divergent and Convergent Processes in Complex Information Tasks
Abstract Large language models are increasingly used to support complex information tasks. However, most systems still rely on linear conversational interfaces that may not align well with workflows requiring parallel exploration and iterative integration. To examine whether nonlinear interaction improves task performance, we developed a graphical interface that supports both divergent and convergent processes throughout the task.
Telecoupling Perspective on the Evolution and Driving Factors of Virtual Cropland Networks in Global Wheat Trade
Submitted: 06 January 2026 You are already at the latest version International agricultural trade plays a crucial role in balancing the global food supply and demand while facilitating the cross-regional allocation of cropland resources. This study examines the virtual cropland flows embedded in international wheat trade. Utilizing the telecoupling framework and wheat trade data from eight time points between 1995 and 2023, we developed a global virtual-cropland-flow network.
Type 2 diabetes mellitus increases surgical sperm retrieval but preserves semen quality and cumulative live birth rate
Keywords type 2 diabetes mellitus male infertility semen analysis surgical sperm retrieval propensity score matching cumulative live birth INTRODUCTION Diabetes mellitus (DM) affects over 525 million adults globally, with males exhibiting higher susceptibility and more severe reproductive system sequelae(Desai et al., 2023).
Powering AI: Can Taiwan Keep the Lights On Amid the AI Boom?
As Taiwan navigates its first summer without nuclear power, the rise of AI is reshaping the island’s energy future—fueling demand, reviving nuclear debates, and exposing deep tensions in its transition to cleaner, more flexible electricity sources. This is Part II of a two-part story. Part I can be found here. In Taiwan’s current planning for AI-related electricity demand, the largest share comes from the upstream semiconductor industry.
Powering AI: How Much Electricity Will Taiwan Need to Fuel Its AI Ambitions?
Taiwan’s first summer without nuclear power highlights its energy transition challenges, as surging AI-related electricity demand and opaque government planning spark public concern and environmental scrutiny. This is Part I of a two-part story. Part II can be found here.
Primary Esophageal Neuroendocrine Carcinoma: Its Clinical, Pathologica
Back to Journals » Cancer Management and Research » Volume 18 Authors Zhang L, Zhou S, Gong Z, Wu M, Zhou B, Li X, Li J, Ding S Received 20 August 2025 Accepted for publication 1 January 2026 Published 20 January 2026 Volume 2026:18 Pages 1—12 DOI https://doi.org/10.2147/CMAR.S562173 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Chien-Feng Li Lingjuan Zhang,1 Shengli Zhou,2 Zhiquan Gong,2 Man Wu,1 Bingxi Zhou,1...
Global Existence and Large Time Behavior of Classical Solutions to the Incompressible Inhomogeneous Kinetic‐Fluid Model With Energy Exchanges
In this paper, we concentrate on a kinetic-fluid model with energy exchanges, which contains a Vlasov–Fokker–Planck equation for the particles and an incompressible inhomogeneous Navier–Stokes system with heat conductivity for the fluid. The two parts in the model twist together via the momentum and energy exchanges revealing the interaction between the fluid and the particles.
Associations Between Inflammatory Potential of Diet with the Risk of All-Cause Mortality and Greenhouse Gas Emissions in Chinese Adults
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Plant-Based Diet Indices with Greenhouse Gas Emissions and Risk of Cardiometabolic Diseases and All-Cause Mortality: Longitudinal China Cohort Study
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
TAB2 Promotes Immune Escape and Chemoresistance Through NF‐κB Pathway Activation in Cervical Cancer
ALDH Aldehyde Dehydrogenase BAY 11–7082 NF-κB Inhibitor BMI1 B cell-specific Moloney murine leukaemia virus integration site 1 CC cervical cancer CCK-8 Cell Counting Kit-8 CDDP Cisplatin CO2 carbon dioxide CSCs cancer stem cells DEAB Diethylaminobenzaldehyde DED dry eye disease DMEM Dulbecco's Modified Eagle's Medium DNA Deoxyribonucleic Acid ECL Enhanced Chemiluminescence EGF Epidermal Growth Factor EMT Epithelial-Mesenchymal Transition FBS foetal bovine serum FITC/PI Fluorescein...
Effects of Sesuvium portulacastrum Floating Treatment Wetlands on Nitrogen Removal and Carbon Sequestration in Aquaculture Water
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Land Use Change in a Typical Transect in Northern China and Its Impact on the Ecological Environment
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing center
Abstract The NLRP3 inflammasome is a multi-protein molecular machine that mediates inflammatory responses in innate immunity. Its dysregulation has been linked to a large number of human diseases. Using cryogenic fluorescence-guided focused-ion-beam (cryo-FIB) milling and electron cryo-tomography (cryo-ET), we obtained 3-D images of the NLRP3 inflammasome in situ at various stages of its activation at macromolecular resolution.
A Multivariate Time Series Prediction Method Based on Convolution-Residual Gated Recurrent Neural Network and Double-Layer Attention
1. Introduction Time series data are numerical values used in complex networked systems to describe objects that vary over time [1,2,3]. The matrix X = x 1 , x 2 , … , x m = ( x 1 , x 2 , … , x k ) T is used as the mathematical expression for the time series, with m representing the number of exogenous driving variables, and the meaning of k is the data length of the time series. A univariate time series occurs when m= 1, while a multi-variate time series occurs when m is greater than 1 [4].
Exploring amyotrophic lateral sclerosis patients’ experiences of psychological distress during the disease course in China: a qualitative study
Psychological Stress Motor neurone disease Qualitative research methods can delve deeply into and describe participants’ experiences within their social, demographic and clinical backgrounds. The diverse social backgrounds of amyotrophic lateral sclerosis (ALS) patients offer the broadest perspectives and experiences for research. Understanding the psychological distress journey of ALS patients aids in providing targeted psychological guidance for them.
Antibiotics | Free Full-Text | The Clinical Characteristics and Antimicrobial Resistance of Staphylococcus aureus Isolated from Patients with Staphylococcal Scalded Skin Syndrome (SSSS) in Southwestern China
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Synthetic BZLF1-targeted transcriptional activator for efficient lytic induction therapy against EBV-associated epithelial cancers - Nature Communications
Abstract The unique virus-cell interaction in Epstein-Barr virus (EBV)-associated malignancies implies targeting the viral latent-lytic switch is a promising therapeutic strategy. However, the lack of specific and efficient therapeutic agents to induce lytic cycle in these cancers is a major challenge facing clinical implementation. We develop a synthetic transcriptional activator that specifically activates endogenous BZLF1 and efficiently induces lytic reactivation in EBV-positive cancer cells.
Residential load forecasting based on symplectic geometry mode decomposition and GRU neural network with attention mechanism
CONFLICT OF INTEREST STATEMENT The authors declare that there is no conflict of interests and competing interests that could have appeared to influence the work reported in this article. REFERENCES 1, , , , , . Short-term residential load forecasting based on LSTM recurrent neural network. IEEE Trans Smart Grid. 2019; 10(1): 841-851. 2, , . Clustering electricity consumers using high-dimensional regression mixture models. Appl Stochast Mod Bus Ind. 2020; 36: 159-177. 3, , , , , .
Potassium-modified calcium-ferrate-catalyzed hydrogenation of carbon dioxide to produce light olefins
Potassium-modified calcium-ferrate-catalyzed hydrogenation of carbon dioxide to produce light olefins† Hydrogenating CO2 to produce light olefins is a highly promising route for olefin synthesis. However, the premise of achieving a high yield is to develop a catalyst with a high conversion rate, selectivity, and stability. This paper reports a Ca2−xKxFe2O5 catalyst with an CO2 conversion of up to 46%, a light olefin selectivity of 34.59%, and an olefin-alkane molar ratio of 8.31.
Clinical features and a prediction model for early prediction of compo
Background Chlamydia psittaci (C. psittaci) is a Gram-negative intracellular bacterium, which is mainly transmitted between birds, and occasionally transmitted to humans by infected birds. Recent studies have shown that C. psittaci has the potential to evolve human-to-human transmission via various routes.1 The severity of C.
Associations between the inflammatory potential of diets with adherence to plant-based dietary patterns and the risk of new-onset cardiometabolic diseases in Chinese adults: findings from a nation-wide prospective cohort study
Associations between the inflammatory potential of diets with adherence to plant-based dietary patterns and the risk of new-onset cardiometabolic diseases in Chinese adults: findings from a nation-wide prospective cohort study† Aims: convincing evidence is still limited for the validation of associations between the inflammatory potential of diets, based on the dietary inflammatory index (DII), and cardiometabolic outcomes.
Autophagy Regulators in Cancer
Abstract : Autophagy plays a complex impact role in tumor initiation and development. It serves as a double-edged sword by supporting cell survival in certain situations while also triggering autophagic cell death in specific cellular contexts. Understanding the intricate functions and mechanisms of autophagy in tumors is crucial for guiding clinical approaches to cancer treatment. Recent studies highlight its significance in various aspects of cancer biology.
Frontiers | 2-NBDG Uptake in Gossypium hirsutum in vitro ovules: exploring tissue-specific accumulation and its impact on hexokinase-mediated glycolysis regulation
Introduction Glucose metabolism is a fundamental process for maintaining cellular homeostasis and providing energy for the growth and development of organisms. In plants, glucose serves as a central building block for the synthesis of complex carbohydrates, including cellulose, hemicellulose, and pectin, which collectively form the cell wall (York et al., 1986; Heredia et al., 1995).
An adaptive three-dimensional hydrodynamic focused microfluidic impedance flow cytometer
An adaptive three-dimensional hydrodynamic focused microfluidic impedance flow cytometer Yang Zhou, Jiao Wang, TING LIU, Man Wu, Yuwei Lan, Chunping Jia and Jianlong Zhao Abstract Microfluidic impedance cytometry is emerging as a label-free, low-cost and portable solution for cell analysis. Impedance-based cell or particle characterization is provided by microfluidic and electronic devices.
Associations between Conventional and Emerging Indicators of Dietary Carbohydrate Quality and New-Onset Type 2 Diabetes Mellitus in Chinese Adults
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
The natural compound neobractatin inhibits cell proliferation mainly by regulating the RNA binding protein CELF6
The natural compound neobractatin inhibits cell proliferation mainly by regulating the RNA binding protein CELF6† ZhaoQing Zheng,‡ab JiaQi Tan,‡ab Juan Zhang,c Man Wu,ab Gan Chen,ab Zhuo Li,ab XiaoQin Shi,ab WenWei Fu,ab Hua Zhou,d YuanZhi Lao,*ab Li Zhang*ab and HongXi Xu *ab Author affiliations * Corresponding authors a School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China E-mail: laurence_ylao@163.com, zhangli1003ecpu@126.com, xuhongxi88@gmail.com b...
In vivo hemodynamic visualization of berberine-induced effect on the cerebral cortex of a mouse by photoacoustic tomography
Dan Wu, Xiuyun Guo, Ruihuan Cui, Man Wu, Qiquan Shang, and Huabei Jiang Author Affiliations Dan Wu,1,2 Xiuyun Guo,1,2 Ruihuan Cui,1,2 Man Wu,1,2 Qiquan Shang,1,2 and Huabei Jiang1,2,3,* 1School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China 2Center for Information in Biomedicine, University of Electronic Science and Technology of China, Sichuan, China 3Department of Medical Engineering, University of South Florida,...
RNA-Seq-Mediated Transcriptome Analysis of a Fiberless Mutant Cotton and Its Possible Origin Based on SNP Markers
As the longest known single-celled trichomes, cotton (Gossypium L.) fibers constitute a classic model system to investigate cell initiation and elongation. In this study, we used a high-throughput transcriptome sequencing technology to identify fiber-initiation-related single nucleotide polymorphism (SNP) markers and differentially expressed genes (DEGs) between the wild-type (WT) Upland cotton (G. hirsutum) Xuzhou 142 and its natural fuzzless-lintless mutant Xuzhou 142 fl.
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