Manav Kapoor

Abstract Naturally occurring loss-of-function variants in human genes enable drug target discovery because they mimic pharmacological inhibition of proteins. However, the study of these genetic variants is constrained by their rarity. Sequencing of diverse populations, particularly those enriched in familial relatedness, has been postulated to promote discovery of rare genetic variants1,2,3.

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Manav Kapoor is a Global Technical Product Leader at Amazon, leading AI/ML-driven product innovations that protect millions of customers. From late November 2024 up to Black Friday 2025, something strange happened. AI-powered shopping agents drove an 805% increase in traffic to U.S. retail sites, generating "over $22 billion in global online sales." Software was browsing, comparing and buying on behalf of real people—no clicks required.