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Manoubia Saidani on Muck Rack

Manoubia Saidani

As seen in: Nature, MDPI
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Articles

IJMS | Free Full-Text | Generating Functional and Highly Proliferative Melanocytes Derived from Human Pluripotent Stem Cells: A Promising Tool for Biotherapeutic Approaches to Treat Skin Pigmentation Disorders

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By Manoubia Saidani, Margot Jarrige, Hélène Polvèche, Annabelle Darle
| MDPI
Abstract : Melanocytes are essential for skin homeostasis and protection, and their loss or misfunction leads to a wide spectrum of diseases. Cell therapy utilizing autologous melanocytes has been used for years as an adjunct treatment for hypopigmentary disorders such as vitiligo. However, these approaches are hindered by the poor proliferative capacity of melanocytes obtained from skin biopsies.
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Pathological modelling of pigmentation disorders associated with Hutchinson-Gilford Progeria Syndrome (HGPS) revealed an impaired melanogenesis pathway in iPS-derived melanocytes

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By Alessandra Lo Cicero, Manoubia Saidani, Jennifer Allouche, Anne Laure Egesipe
| Nature Verified
HGPS Fibroblasts (13-8243) used in this study was isolated from a patient biopsy taken in the Assistance Publique Hôpitaux de Marseille during diagnostic procedures (referred as HGPS_1 in this study). HGPS Fibroblasts (AG001972) used in this study was provided by Coriell Cell Repository (Camden, USA) (referred as HGPS_2 in this study).
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