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Marcel Kool

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Articles by Marcel Kool

Author Correction: Multidimensional profiling of heterogeneity in supratentorial ependymomas

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By Daeun Jeong, Sara Danielli, Kendra K. Maaß, David R. Ghasemi, Svenja K. Tetzlaff, Ekin Reyhan, Li Jiang, Shashank Katiyar, Julia Sundheimer, Costanza Lo Cascio, Sina Neyazi, Elsa Couvillon, Sophia Castellani, Maria F. Pazyra-Murphy, Matthew Mullally, Marc Philipp Dehler, Bernhard Englinger, Andrezza Nascimento, Joana Marques, Rebecca Haase, Cuong Nguyen, cường nguyễn, Alicia-Christina Baumgartner, Jacob S Rozowsky, Olivia A. Hack, McKenzie L. Shaw, Daniela Lötsch-Gojo, Katharina Bruckner, Andrey Korshunov, Stefan M. Pfister, Marcel Kool, Tomasz Nowakowski Verified, Johannes Gojo, Lissa C. Baird, Sanda Alexandrescu, Kristian W. Pajtler, Mariella G. Filbin
| Nature Verified
Correction to: Nature https://doi.org/10.1038/s41586-026-10214-2 Published online 11 March 2026 In the version of the article initially published, the oncoplot in Fig. 1a contained errors which have now been corrected. These include mismatched color of fusion genes, three samples incorrectly included in the plot, the sex of cell line and PDX of BT165, and missing scRNAseq annotation of sample STEPN-14. These errors do not affect the results or conclusions of this study.
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By Chiara Lago, Gloria Leva, Marcel Kool, Evelina Miele, Luca Tiberi
| Nature Verified
Abstract Ependymoma and medulloblastoma are among the most common malignant pediatric brain tumors and contribute significantly to morbidity and mortality in affected children. Robust models for investigating these tumors’ biology and heterogeneity, and exploring alternative therapeutic options, are currently limited.
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Multidimensional profiling of heterogeneity in supratentorial ependymomas

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By Daeun Jeong, Sara Danielli, David R. Ghasemi, Svenja K. Tetzlaff, Ekin Reyhan, Li Jiang, Julia Sundheimer, Costanza Lo Cascio, Sina Neyazi, Sophia Castellani, Maria F. Pazyra-Murphy, Bernhard Englinger, Andrezza Nascimento, Joana Marques, Rebecca Haase, CUONG NGUYEN, cường nguyễn, Jacob S Rozowsky, Olivia A. Hack, McKenzie L. Shaw, Daniela Lötsch-Gojo, Katharina Bruckner, Andrey Korshunov, Stefan M. Pfister, Marcel Kool, Tomasz Nowakowski Verified, Johannes Gojo, Lissa C. Baird, Sanda Alexandrescu, Kristian W. Pajtler, Mariella G. Filbin, Kendra K. Maaß, Shashank Katiyar, Elsa Couvillon, Matthew Mullally, Marc Philipp Dehler, Alicia-Christina Baumgartner
| Nature Verified
Abstract Supratentorial ependymomas are aggressive childhood brain cancers that retain features of neurodevelopmental cell types1 and segregate into molecularly and clinically distinct subgroups2,3, suggesting different developmental roots. The developmental signatures, as well as microenvironmental factors, underlying aberrant cellular transformation and behaviour across each supratentorial ependymoma subgroup are unclear.
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Paediatric Therapeutic Development Workshop on rhabdoid tumours - British Journal of Cancer

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By Jan J. Molenaar, Jaclyn A. Biegel, Patricia Blanc, Susan N. Chi, Sam Daems, Laura Danielson, Jarno Drost, Michael C. Frühwald, Amar Gajjar, James Geller, annie huang, Pascal D. Johann, Pamela R Kearns, Karsten Nysom, Suzanne O’Connor, Michael Ortiz, Jenny Parker, Seema Patel, Sheena M Patel, Charles Roberts, Daniel Williamson, Joanna S. Yi, Andrew Pearson, David Jenkinson Verified, Marcel Kool, Franck Bourdeaut, Innovative Therapies, Claudia Montiel Equihua, Itziar Areso, Niels E. Franke
| Nature Verified
Abstract Rhabdoid tumours (RT) are malignancies of the central nervous system, kidneys, liver and soft tissues that most commonly affect very young children with survival rates below 30% in high-risk cohorts. Treatment entails surgery, intensive chemotherapy and radiotherapy, associated with substantial short- and long-term toxicities. There is an unmet need to develop targeted therapies for RT to improve patient outcomes and mitigate the toxicities of current therapy.
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IGSF11-VISTA is a critical and targetable immune checkpoint axis in diffuse midline glioma

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By Raphaël Collot, Cristian Ruiz-Moreno, Celina Honhoff, Daan J. Kloosterman, Hannah Johnson, Jens Bunt, Ravian van Ineveld, Brigit M. te Pas, Femke Ringnalda, Pierre Robe, Marcel Kool, Jennifer Cochran, Mariette Kranendonk, Dannis van Vuurden, Esther Hulleman, Ellen J Wehrens, Anoek Zomer, Hendrik G. Stunnenberg, Anne Rios, Thijs J.M. van den Broek, Amber K.L. Wezenaar, Hendrikus C.R. Ariese, Britt M.T. Vervoort, Amal Jeiroshi, Emma Bokobza, Heggert G. Rebel, Marc van de Wetering
| Cell Press Verified
Keywords diffuse midline glioma spatial multi-omics profiling cancer-immune landscape microglia-cancer interaction IGSF11-VISTA immune checkpoint Introduction Diffuse midline glioma (DMG) is a highly aggressive pediatric brain tumor lacking curative treatments.1,2,3 DMG is commonly characterized by a histone H3 lysine 27-to-methionine (H3K27M) mutation, predominantly the H3.3K27M variant.4 This K27M mutation is often accompanied by mutations in oncogenes and tumor suppressor genes, with TP53...
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Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma

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By Flavia Bernardi, Jacob Torrejon, Irene Basili, Randy Van Ommeren, Véronique Marsaud, Hua Yu, Julie Talbot, Judith Souphron, Emilie Indersie, Antoine Forget, Benjamin Bonneau, Alexane Massiot, Coralie Alcazar, Laurine Figeac, Emma Bonerandi, Gabriele Cancila, Olga Sirbu, Navneesh Yadav, Dinesh Mohanakrishnan, Bérangère Lombard, Damarys Loew, Patrick Poullet, Stephane Liva, Marta Lovino, I-Hsuan Lin, Takuma Nakashima, Tarek Gharsalli, Paul Nicolas, Naoji Yubuki, Roberto Ribas, Benoit Colsch, Emeline Chu-Van, Florence Anne Castelli, Sophie Leboucher, Charlene Lasgi, Laetitia Besse, Marie-Noëlle Soler, Valentina Re, Nathalie Planque, Namal Abeysundara, Polina Balin, Hao Wang, Haipeng Su, Xiaochong Wu, Florence M.G. Cavalli, Olivier Saulnier, Elisa Ficarra, Lucia Di Marcotullio, Kohei Kumegawa, Reo Maruyama, Daisuke Kawauchi, Daniel Picard, Laurent Riffaud, Chloé Puiseux, Yassine Bouchoucha, Sophie Huybrechts, Marie Simbozel, Franck Bourdeaut, Pascale Varlet, Stéphanie Puget, Thomas Blauwblomme, Mamy Andrianteranagna, Julien Masliah Planchon, Aurelien Dugourd, Julio Saez-Rodriguez, Emmanuel Barillot, Nicolas Servant, Loredana Martignetti, Jeremy Rich, Marcel Kool, Stefan M. Pfister, Sameer Agnihotri, Hiromichi Suzuki, Marjorie Fanjul, Won-Jing Wang, Jin-Wu Tsai, Ramon C. Sun, Kévin Beccaria, Christelle Dufour, Jean-Emmanuel Sarry, Kulandaimanuvel Antony Michealraj, Michael Taylor Verified, Olivier Ayrault
| Cell Press Verified
Keywords pediatric cancer medulloblastoma multiomics integration proteomics phosphoproteomics transcriptomics metabolomics lipid biosynthesis lipid droplets lipid oxidative stress Get full text access Log in, subscribe or purchase for full access. References 1. Louis, D.N. ∙ Perry, A. ∙ Reifenberger, G. ... The 2016 World Health Organization Classification of Tumors of the Central Nervous System: A Summary Acta Neuropathol. 2016; 131:803-820 2. Ramaswamy, V. ∙ Remke, M. ∙ Bouffet, E. ...
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Advancing CNS tumor diagnostics with expanded DNA methylation-based classification

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By Martin Sill, Daniel Schrimpf, Areeba Patel, Dominik Sturm, Natalie Jäger, Philipp Sievers, Leonille Schweizer, Rouzbeh Banan, David E. Reuss, Abigail K. Suwala, Andrey Korshunov, Damian Stichel, Annika K Wefers, Ann-Christin Hau, Henning Boldt, Patrick N. Harter, Zied Abdullaev, Jamal Benhamida, Daniel Teichmann, Arend Koch, Jürgen Hench, Stephan Frank, Martin Hasselblatt, Sheila Mansouri, Jonathan Serrano, Jonas Ecker, Michael Taylor Verified, Vijay Ramaswamy, Anna S. Berghoff, Brigitte Bison, Mirjam Blattner-Johnson, Ivo Buchhalter, Gabriele Calaminus, Nicola Dikow, Hildegard Dohmen, Philipp Euskirchen, Gudrun Fleischhack, Amar Gajjar, Nicolas U. Gerber, Marco Gessi, Gerrit H. Gielen, Astrid K. Gnekow, Nicholas G Gottardo, Christine Haberler, Stefan Hamelmann, Jordan Hansford, Christian Hartmann, Frank L. Heppner, Pablo Hernáiz Driever, Katja von Hoff, Ulrich W. Thomale, Michael C. Frühwald, Christof M. Kramm, Ulrich Schüller, Jens Schittenhelm, Martin Schuhmann, Marco Stein, Petra Ketteler, Marc Ladanyi, Nada Jabado, Barbara Jones, Chris Jones, Matthias A. Karajannis, Uwe Kordes, Annekathrin Reinhardt, Christian Kölsche, Katrin Lamszus, Peter Lichter, Sybren L.N. Maas, Christian Mawrin, Michel Mittelbronn, Camelia-Maria Monoranu, Wolf Mueller, Martin Mynarek, Paul A. Northcott, Kristian W. Pajtler, Werner Paulus, Arie Perry, Ingmar Blümcke, Karl H. Plate, Michael Platten, Matthias Preusser, Torsten Pietsch, Marco Prinz, Guido Reifenberger, Bjarne W. Kristensen, Marcel Kool, Volker Hovestadt, David Ellison, Thomas Jacques, Pascale Varlet, Nima Etminan, Michael Weller, Christine White, Olaf Witt, Christel Herold-Mende, Jürgen Debus, Sandro M. Krieg, Wolfgang Wick, Matija Snuderl, Sebastian Brandner, Cynthia Hawkins, Craig M Horbinski, Christian Thomas, Pieter Wesseling, Andreas von Deimling, David Capper, Stefan M. Pfister, Felix Sahm, Florian Selt, Rolf Buslei, Volkmar Hans, Stephan Tippelt, Ralf Ketter, Patricia Kohlhof, Ken Aldape
| Cell Press Verified
ArticleOnline nowOpen access 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany 2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany 3Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany 4Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany 5Division of Pediatric...
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Advancing CNS tumor diagnostics with expanded DNA methylation-based classification

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By Martin Sill, Daniel Schrimpf, Areeba Patel, Dominik Sturm, Natalie Jäger, Philipp Sievers, Leonille Schweizer, Rouzbeh Banan, David E. Reuss, Abigail K. Suwala, Andrey Korshunov, Damian Stichel, Annika K Wefers, Ann-Christin Hau, Henning Boldt, Patrick N. Harter, Zied Abdullaev, Jamal Benhamida, Daniel Teichmann, Arend Koch, Jürgen Hench, Stephan Frank, Martin Hasselblatt, Sheila Mansouri, Jonathan Serrano, Jonas Ecker, Florian Selt, Michael Taylor Verified, Vijay Ramaswamy, Anna S. Berghoff, Brigitte Bison, Mirjam Blattner-Johnson, Ivo Buchhalter, Rolf Buslei, Gabriele Calaminus, Nicola Dikow, Hildegard Dohmen, Philipp Euskirchen, Gudrun Fleischhack, Amar Gajjar, Nicolas U. Gerber, Marco Gessi, Gerrit H. Gielen, Astrid K. Gnekow, Nicholas G Gottardo, Christine Haberler, Stefan Hamelmann, Volkmar Hans, Jordan Hansford, Christian Hartmann, Frank L. Heppner, Pablo Hernáiz Driever, Katja von Hoff, Ulrich W. Thomale, Stephan Tippelt, Michael C. Frühwald, Christof M. Kramm, Ulrich Schüller, Jens Schittenhelm, Martin Schuhmann, Marco Stein, Petra Ketteler, Marc Ladanyi, Nada Jabado, Barbara Jones, Chris Jones, Matthias A. Karajannis, Ralf Ketter, Patricia Kohlhof, Uwe Kordes, Annekathrin Reinhardt, Christian Kölsche, Katrin Lamszus, Peter Lichter, Sybren L.N. Maas, Christian Mawrin, Michel Mittelbronn, Camelia-Maria Monoranu, Wolf Mueller, Martin Mynarek, Paul A. Northcott, Kristian W. Pajtler, Werner Paulus, Arie Perry, Ingmar Blümcke, Karl H. Plate, Michael Platten, Matthias Preusser, Torsten Pietsch, Marco Prinz, Guido Reifenberger, Bjarne W. Kristensen, Marcel Kool, Volker Hovestadt, David Ellison, Thomas Jacques, Pascale Varlet, Nima Etminan, Michael Weller, Christine White, Olaf Witt, Christel Herold-Mende, Jürgen Debus, Sandro M. Krieg, Wolfgang Wick, Matija Snuderl, Ken Aldape, Sebastian Brandner, Cynthia Hawkins, Craig M Horbinski, Christian Thomas, Pieter Wesseling, Andreas von Deimling, David Capper, Stefan M. Pfister, Felix Sahm
| Cell Press Verified
ArticleVolume 44, Issue 2p340-354.e2Open access 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany 2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany 3Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany 4Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany...
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Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions - Nature Cancer

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By Alexander Beck, Ilon Liu, Jochen Herms, Louisa von Baumgarten, Katharina Bruckner, Sibylle Madlener, Lisa Mayr, Andreas Peyrl, Irene Slavc, Christian Dorfer, Nicole Amberg, Stefan M. Pfister, Lissa C. Baird, Susan N. Chi, Marcel Kool, Volker Hovestadt, Joerg C. Tonn
| Nature Verified
Abstract Embryonal tumor with multilayered rosettes (ETMR) is a pediatric brain tumor with dismal prognosis. Characteristic alterations of the chromosome 19 microRNA cluster (C19MC) are observed in most ETMR; however, the ramifications of C19MC activation and the complex cellular architecture of ETMR remain understudied. Here we analyze 11 ETMR samples from patients using single-cell transcriptomics and multiplexed spatial imaging.
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Notch Signaling between Cerebellar Granule Cell Progenitors

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By Lukas Chavez, Marcel Kool, Stefan M. Pfister
| eneuro.org
Research ArticleResearch Article: Confirmation, Development Toma Adachi, Satoshi Miyashita, Mariko Yamashita, Mana Shimoda, Konstantin Okonechnikov, Lukas Chavez, Marcel Kool, Stefan M. Pfister, Takafumi Inoue, Daisuke Kawauchi and Mikio Hoshino eNeuro 24 March 2021, 8 (3) ENEURO.0468-20.2021; DOI: https://doi.org/10.1523/ENEURO.0468-20.2021 Abstract Cerebellar granule cells (GCs) are cells which comprise over 50% of the neurons in the entire nervous system.
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Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells

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By Jonathan Robson, Marcel Kool, Elaine Julian
| PLOS
Loading metrics Open Access Peer-reviewed Research Article Jonathan P. Robson , Marc Remke, Marcel Kool, Elaine Julian, Andrey Korshunov, Stefan M. Pfister, Geoffrey W. Osborne, Michael D. Taylor, Brandon Wainwright, Brent A. Reynolds Jonathan P. Robson, Marc Remke, Marcel Kool, Elaine Julian, Andrey Korshunov, Stefan M. Pfister, Geoffrey W. Osborne, Michael D. Taylor, Brandon Wainwright, Brent A.
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