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Margaret W. Barbier on Muck Rack

Margaret W. Barbier

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Articles

ABL kinase inactivation induces transcription-replication conflicts and impairs replication fork progression in metastatic small cell lung cancer

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By Jing Gu, Kevin Scott, Arijit Ghosh Verified, Douglas C. Rouse, Jacob P. Hoj, Fengqi Zhang, Boya Gao, Margaret W. Barbier, Lee Zou, Ann Marie Pendergast, Roberto H. Barbier, Michael W. Caminear
| Cell Reports Verified
ArticleVolume 45, Issue 7117699Open access Affiliations & Notes 1Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, United States of America 2Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, United States of America 3Division of Laboratory Animal Resources, Duke University School of Medicine, Durham, NC, United States of America Article Info Publication History: Received June 2, 2025; Revised May 6,...
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Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer - Nature

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By Abbie S. Ireland, Daniel Xie, Sarah B. Hawgood, Ramaswamy Govindan, Charles M. Rudin, Joseph Chan, Margaret W. Barbier
| Nature Verified
Abstract Neuroendocrine and tuft cells are rare chemosensory epithelial lineages defined by the expression of ASCL1 and POU2F3 transcription factors, respectively. Neuroendocrine cancers, including small cell lung cancer (SCLC), frequently display tuft-like subsets, a feature linked to poor patient outcomes1,2,3,4,5,6,7,8,9. The mechanisms driving neuroendocrine–tuft tumour heterogeneity and the origins of tuft-like cancers are unknown.
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