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Mari L. DeMarco on Muck Rack

Mari L. DeMarco

As seen in: Cell Press, Chest
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Articles

Alzheimer disease blood-based biomarkers: Translation from research into clinical use

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By Mari L. DeMarco, Lance A Ladic
| Clinical Laboratory News (ADLM)
Listen to the Clinical Chemistry Podcast Article Lance A Ladic, Mari L DeMarco, Nicholas J Ashton, Andrew J Saykin, Louis B Jacques. Alzheimer’s Disease Blood-Based Biomarkers: Translation from Research into Clinical Use. Clin Chem 2024; 70(11): 1308–14. Guests Dr. Lance Ladic from Siemens Healthineers in Princeton, New Jersey and Dr. Mari DeMarco from St Paul's Hospital and the University of British Columbia in Vancouver, Canada.
Open in Who Shared Issue with article?
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By Andrew Chang, Xinyu Xiang, Jing L. Wang, Carolyn Lee, Jing Wang, Carolyn Lee, Tamta Arakhamia, Chi Wang, Yari Carlomagno, Guoan Zhang, Lauren M. Forgrave, Michael DeTure, Mari L. DeMarco, Casey Cook, Marija Simjanoska, Shikhar Dhingra, Manon Thierry, Jolien Perneel, Bavo Heeman
| Cell Press Verified
Highlights • Cryo-EM structures of brain-derived TMEM106B fibrils from neurodegenerative diseases • Endolysosomal membrane protein TMEM106B C-terminal fragment forms amyloid fibrils • TMEM106B fibrillization is widespread among diverse neurodegenerative proteinopathies • Identification of fibrillization pathway potentially implicated in neurodegeneration Summary Misfolding and aggregation of disease-specific proteins, resulting in the formation of filamentous cellular inclusions, is a...
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Biomarker Development in COPD: Moving from P-Values to Products to Impact Patient Care

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By Zsuzsanna Hollander, Mari L. DeMarco, Mohsen Sadatsafavi, Bruce McManus
| Chest Verified
There is a great interest in developing biomarkers to enable precision medicine and improve health outcomes of patients with chronic obstructive pulmonary disease (COPD). However, biomarker development is extremely challenging and expensive, and translation of research endeavors to date have been largely unsuccessful.
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