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ArticleVolume 45, Issue 8117822Open access Affiliations & Notes 1Department of Medical Physiology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan 2Metabolic Research Laboratories, MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom of Great Britain and Northern Ireland (the) 3Department of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan 4Department of Molecular Diagnosis, Graduate...
ADCC antibody-dependent cellular cytotoxicity GD2 disialoganglioside iNKT cell invariant natural killer T cell iPS-NKT cell induced pluripotent stem cell–derived natural killer T cell 1 Introduction Neuroblastoma is a tumor of the sympathetic nervous system and the most common extracranial solid malignant tumor in children.
Thymus‐derived regulatory T cells (tTregs) play pivotal roles in immunological self‐tolerance and homeostasis. A majority of tTregs are reactive to self‐antigens and are constantly exposed to antigenic stimulation. Despite this continuous stimulation, tTreg and conventional T cell populations remain balanced during homeostasis, but the mechanisms controlling this balance are unknown.
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