Ryo Koyama-Nasu

ArticleVolume 45, Issue 8117822Open access Affiliations & Notes 1Department of Medical Physiology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan 2Metabolic Research Laboratories, MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom of Great Britain and Northern Ireland (the) 3Department of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan 4Department of Molecular Diagnosis, Graduate...

Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Thymic central tolerance is crucial for preventing autoimmunity, but its contribution to tumor immune evasion remains poorly understood.

Ab antibody CTLA-4 cytotoxic T-lymphocyte-associated protein 4 DCs dendritic cells HNSCC head and neck squamous cell carcinoma ICB immune checkpoint blockade IFN interferon LCMV lymphocytic choriomeningitis virus MHC major histocompatibility complex Myl myosin light chain NK natural killer PD-1 programmed cell death 1 PD-L1 programmed cell death-ligand 1 S1P1 sphingosine-1-phosphate receptor 1 TCF1 T cell factor 1 TCR T cell receptor TDLNs tumor-draining lymph nodes Tim-3 T cell...