Máté Lengyel

Affiliations & Notes 1Center for Neural Science, New York University, New York City, NY, USA 2Center for Neural Basis of Cognition, Pittsburgh, PA, USA 3Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA 4Department of Computer Science, Yale University, New Haven, CT, USA 5Department of Cognitive Science, Central European University, Vienna, Austria 6Department of Engineering, University of Cambridge, Cambridge, UK 7Brain Mind Institute and Neuro-X Institute, EPFL,...

Abstract Failing to make decisions that would actively avoid negative outcomes is central to helplessness. In a Bayesian framework, deciding whether to act is informed by beliefs about the world that can be characterised as priors. However, these priors have not been previously quantified. Here we administered two tasks in which 279 participants decided whether to attempt active avoidance actions.

1 INTRODUCTION While over 15% of breast cancer cases develop without an addiction to either estrogen receptors or Her2 receptors, RXR-selective retinoids have a well documented ability to suppress receptor-negative breast cancer formation in transgenic mouse models.1-3 We hypothesized that the rexinoid-dependent suppression of pro-tumorigenic factors in premalignant breast cells represents valid targets for cancer interception and the inhibition of cellular transformation.