Matouš Glanc

Highlights • MAB4/MEL proteins are recruited to the plasma membrane by PINs • PINs, MAB4/MELs, and AGC kinases directly interact in a multiprotein complex • PIN phosphorylation and MAB4/MEL recruitment form a positive feedback loop • MAB4/MELs and AGC kinases maintain PIN polarity by limiting PIN lateral diffusion Summary Polar subcellular localization of the PIN exporters of the phytohormone auxin is a key determinant of directional, intercellular auxin transport and thus a central topic of...

Highlights • NSAIDs exhibit striking activity in shaping Arabidopsis root development • NSAIDs interfere with auxin transport and endomembrane trafficking • NSAID treatments impair actin filament dynamics and endosomal mobility • NSAIDs directly target TWD1, suppressing its chaperone activity and actin dynamics Summary The widely used non-steroidal anti-inflammatory drugs (NSAIDs) are derivatives of the phytohormone salicylic acid (SA).

Highlights • SA modulates root development independently of NPR1-mediated canonical signaling • SA attenuates growth through crosstalk with the auxin transport network • SA upregulates the phosphorylation status of PIN auxin efflux carriers through PP2A • SA directly targets A subunits of PP2A, inhibiting the activity of the complex Summary Plants, like other multicellular organisms, survive through a delicate balance between growth and defense against pathogens.