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Matthew T. Sorbara on Muck Rack

Matthew T. Sorbara

As seen in: Nature, Cell Host & Microbe, Cell Press
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Articles

Transferable genetic toolsets for nonmodel gut Clostridia enable in vivo reversible control of metabolite production

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By Ting-Ting Li, Xi Chen, Leyi Xiao, Wen-Bing Jin, Huiqing Shi, Xiaoyu Yang, Yaping Liu, Matthew T. Sorbara, Chun-Jun Guo, Fangzhao Wang, Yuelin Angelina Tang, Marissa Sim, Jiayan Yoshii Ma
| Nature Verified
Abstract Gut Clostridia species, including commensal members of the Clostridiaceae and Lachnospiraceae families, maintain microbiota homeostasis and influence human health and disease; however, adequate genetic toolsets to study abundant but nonmodel gut Clostridia are lacking. Here we present a set of transferable and modular genetic toolsets that function broadly across phylogenetically diverse gut Clostridia.
Open in Who Shared Issue with article?

Shaping microbiome function with a human milk-oligosaccharide synbiotic

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By Matthew T. Sorbara
| Cell Press Verified
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Open in Who Shared View Duplicates (10) Issue with article?

Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation

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By Simone Becattini, Matthew T. Sorbara, Sohn Kim, Eric Littmann
| Cell Host & Microbe Verified
Highlights • Acute immune activation alters intestinal microbiota gene transcription within hours • Microbial transcriptional signatures include stress- and metabolism-associated genes • Microbiota composition and the type of immune stimulus impact bacterial responses • The intestinal metabolome is rapidly reshaped by immune activation of the host Summary The gut microbiota produces metabolites that regulate host immunity, thereby impacting disease resistance and susceptibility.
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