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Mattia Conte

As seen in: Nature, MDPI, BioRxiv, Cell Reports, Physical Review B

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Articles

Phase separation of ecDNA condensates establishes in-trans contact domains that boost selective MYC regulatory interactions

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By Mattia Conte, Tommaso Matteuzzi, Andrea Esposito, Sumanta Kundu, Andrea M. Chiariello, Simona Bianco, Francesca Vercellone, Wenbo Li, Mario Nicodemi, Lana Al Hasani
| Nature Verified
Abstract Extrachromosomal DNAs (ecDNAs) are circular DNA elements found in many human cancers, often carrying oncogenes and regulatory elements. In COLO320-DM colorectal cancer cells, MYC-harboring ecDNAs form nuclear clusters associated with oncogene overexpression, but the mechanisms underlying their aggregation and gene upregulation remain unclear.
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An integrated view of the structure and function of the human 4D nucleome - Nature

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By Job Dekker, Johan H. Gibcus, Oliver J. Rando, Derek H. Janssens, Steven Henikoff, Alexander Kukalev, Willemin Andréa, Warren Winick-Ng, Ana Pombo, Miao Yu, PRADEEP KUMAR, Andrew S. Belmont, Takayo Sasaki, Bas van Steensel, Minji Jennifer Kim, Yijun Ruan, Sofia A Quinodoz, Prashant Bhat, Mitchell Guttman, Shu Chien, Yuan Liu, Sergey V. Venev, Dariusz Plewczynski, Christoph J. Thieme, Teresa Szczepińska, Mateusz Chiliński, Mattia Conte, Andrea Esposito, Ruochi Zhang, Xingzhao Wen, Andrea Maria Chiariello, Simona Bianco, Ming Hu, Yun Li Verified, Peter J. Park, Clara Bakker, Ting Wang, Daofeng Li, Xiaotao Wang, Mario Nicodemi, Sheng Zhong, Jennifer E. Phillips-Cremins, David Gilbert, Katherine S. Pollard, Jian Ma, William Noble
| Nature Verified
Abstract The dynamic three-dimensional (3D) organization of the human genome (the 4D nucleome) is linked to genome function. Here we describe efforts by the 4D Nucleome Project1 to map and analyse the 4D nucleome in widely used H1 human embryonic stem cells and immortalized fibroblasts (HFFc6).
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Polymer Physics Models Reveal Structural Folding Features of Single-Molecule Gene Chromatin Conformations

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By Mattia Conte, Alex Abraham, Andrea Esposito, Liyan Yang
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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