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Abstract Structural variants (SVs) are increasingly recognized as important contributors to oncogenesis through their effects on 3D genome folding. Recent advances in whole-genome sequencing have enabled large-scale profiling of SVs across diverse tumors, yet experimental characterization of their individual impact on genome folding remains infeasible.
ArticleOnline nowOpen access Affiliations & Notes 1Gladstone Institutes, San Francisco, CA 94158, USA 2University of California, San Francisco, San Francisco, CA 94158, USA 3Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 4Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA 5Leibniz Institute of Virology, Hamburg, Germany 6Institute of Infection Research and Vaccine Development, University Medical Center...
Correction to: Nature https://doi.org/10.1038/s41586-025-09593-9 Published online 22 October 2025 During the proof stage of this paper, the description of the statistical method in the legend for Fig. 4e was incorrectly edited to “Two-sided Fisher’s exact test, p value reported on graph.” The correct statistical method used, as stated during the peer review process, was a directional score test for equality of proportions using a Chi-square approximation.
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