Max Jan
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Articles by Max Jan
Genomic correlates of clinical CAR T cell activity
Editor’s summary Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Editor’s summary Chimeric antigen receptor T cell (CAR T cell) therapies are generated from human T cells and carry germline variants that may affect their function. Leick et al.
Clinical validation of a high-performance somatic exome sequencing assay: from target-enrichment strategy to variant calling
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Abstract Clinical whole-exome sequencing (WES) has revolutionized clinical diagnostics by enabling scalable, cost-effective molecular profiling to detect somatic variants and identify novel therapeutic targets. In particular, the clinical evaluation of somatic variants relies on both high-quality sequencing data and robust variant detection with rapid turnaround times.
By Junko Tsuji, Micah Rickles-Young, Justin Abreu, Alyssa Friedman, Caroline Petersen, J. Bryan, Konrad Scheffler, Edyta Malolepsza, Mark Fleharty, Katie Larkin, Kenneth J. Livak, Shuqiang Li, David A Reardon, Catherine J. Wu, Patrick A. Ott, Heidi Rehm, Max Jan, Chip Stewart, Gad Getz, Varun Jain, Severine Catreux, Carrie L. Cibulskis, Niall J Lennon, Taylor O’Connell, Theo Heyns, Fanny Dao
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Nature
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The Heir of the Lost Order
Max Jan · Follow 10 min read · -- Chapter 1: The Ordinary Life Sophie lived a life most people would call perfect. At 15, she was the only child of Paul and Anna, who showered her with love and attention. They were an ordinary, God-fearing Christian family living in Manila, a quiet town in South India. The kind of town where everyone knew everyone, and life flowed at its own steady, predictable pace.
"Clonal Hematopoiesis is Associated With Protection From Alzheimer's Di" by Hind Bouzid, Julia A Belk et al.
Home > UTHealth > SPH > Journal Articles > 536 Journal Articles Humans, Clonal Hematopoiesis, Alzheimer Disease, Hematopoiesis, Hematopoietic Stem Cells, Precancerous Conditions, Mutation DOWNLOADS COinS
A molecular glue approach to control the half-life of CRISPR-based technologies
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SEAKER cells coordinate cellular immunotherapy with localized chemotherapy
Tumor antigen escape and T cell dysfunction limit the effectiveness of chimeric antigen receptor (CAR) T cell therapies. To overcome these challenges, Gardner et al. engineered synthetic enzyme-armed killer (SEAKER) cells to coexpress a CAR and a prodrug-activating enzyme to orchestrate a dual immunologic and pharmacologic attack at the tumor site. Purchase access to all full-text HTML articles for 6 or 36 hr at a low cost. Click here to explore this opportunity.
Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide
Flipping the switch on T cells Cell-based treatments such as chimeric antigen receptor (CAR) T cells have been finding increasing applications against cancer and other disorders. However, these treatments can have side effects, and it is difficult to stop the activity of an overactive cell-based therapy once it is inside a patient. To improve regulation of CAR T cell treatment, Jan et al. developed a switch-based system for activating and inactivating these cells.
Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide
Max Jan https://orcid.org/0000-0002-7071-5517, Irene Scarfò https://orcid.org/0000-0002-5545-3248, Rebecca C. Larson https://orcid.org/0000-0003-0174-061X, Amanda Walker, Andrea Schmidts https://orcid.org/0000-0001-7035-1584, Andrew A. Guirguis https://orcid.org/0000-0003-3134-0596, Jessica A. Gasser, … Show All … , Mikołaj Słabicki https://orcid.org/0000-0001-6317-9296, Amanda A. Bouffard, Ana P. Castano, Michael C. Kann, Maria L.
Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide
Flipping the switch on T cells Cell-based treatments such as chimeric antigen receptor (CAR) T cells have been finding increasing applications against cancer and other disorders. However, these treatments can have side effects, and it is difficult to stop the activity of an overactive cell-based therapy once it is inside a patient. To improve regulation of CAR T cell treatment, Jan et al. developed a switch-based system for activating and inactivating these cells.
Techno Mastering?
Guten Tag, da ich neu in diesem Forum bin Stelle ich mir die Frage ob es hier auch Leute giebt die Interesse daran haben Techno Tracks zu mastern. Ich selber produziere Techno und habe nun zwei Tracks in den Startlöchern. Ich bin allerdings noch auf der Suche nach einem anständig klingendem Mastering.
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